SCHEDULE 13G/A 0000902664-24-001825 0001910456 XXXXXXXX LIVE 4 Ordinary Shares, nominal value $0.025 per share 09/30/2025 0001855129 GH Research PLC G3855L106 JOSHUA DAWSON HOUSE DAWSON STREET DUBLIN 2 L2 RY95 Rule 13d-1(c) LYNX1 CAPITAL MANAGEMENT LP DE 0.00 8601189.00 0.00 8601189.00 8601189.00 N 13.9 PN WESTON NICHOLS X1 0.00 8601189.00 0.00 8601189.00 8601189.00 N 13.9 IN GH Research PLC Joshua Dawson House, Dawson Street, Dublin 2 L2, D02 RY95, Ireland This statement is filed by: (I) Lynx1 Capital Management LP (the "Investment Manager"), a Delaware limited partnership, and the investment manager to Lynx1 Master Fund LP (the "Lynx1 Fund") and a managed account, with respect to the ordinary shares, nominal value $0.025 per share ("Ordinary Shares"), of GH Research PLC, an Irish public limited company (the "Company"), directly held by the Lynx1 Fund and the managed account; and (ii) Mr. Weston Nichols ("Mr. Nichols"), the sole member of Lynx1 Capital Management GP LLC, the general partner of the Investment Manager, with respect to the Ordinary Shares directly held by the Lynx1 Fund and the managed account. The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons." The filing of this statement should not be construed as an admission that any of the foregoing persons or any Reporting Person is, for the purposes of Section 13 of the Securities Exchange Act of 1934, the beneficial owner of the securities reported herein. Lynx1 Capital Management LP D81 Calle C Suite 301, PMB 1202 Dorado, PR, 00646-2051 Weston Nichols c/o Lynx1 Capital Management LP D81 Calle C Suite 301, PMB 1202 Dorado, PR, 00646-2051 Investment Manager - Delaware Mr. Nichols - United States of America Y The information required by Item 4(a) is set forth in Row 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The percentage set forth in this Schedule 13G is calculated based upon an aggregate of 62,029,395 Ordinary Shares outstanding as of June 30, 2025, as reported in Exhibit 99.1 to the Company's Report of Foreign Issuer on Form 6-K, filed with the Securities and Exchange Commission on August 7, 2025. 13.9% The information required by Item 4(c)(i) is set forth in Row 5 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(ii) is set forth in Row 6 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(iii) is set forth in Row 7 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(iv) is set forth in Row 8 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Y N See Item 2(a). The Lynx1 Fund has the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the Ordinary Shares reported herein. Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. LYNX1 CAPITAL MANAGEMENT LP /s/ Weston Nichols 11/14/2025 WESTON NICHOLS /s/ Weston Nichols 11/14/2025