X0508 4 2025-01-30 0001434647 ZEVRA THERAPEUTICS, INC. ZVRA 0001910132 Quartel Adrian W C/O ZEVRA THERAPEUTICS, INC. 1180 CELEBRATION BOULEVARD, SUITE 103 CELEBRATION FL 34747 1 Chief Medical Officer 0 Stock Option (right to buy) 8.02 2025-01-30 4 A 0 68000 0 A 2035-01-29 Common Stock 68000 68000 D Restricted Stock Unit 2025-01-30 4 A 0 34000 0 A Common Stock 34000 34000 D Grant to the Reporting Person of a stock option under the Issuer's Amended and Restated 2014 Equity Incentive Plan. The option will vest and become exercisable in four equal annual installments beginning on the first anniversary of the grant date, subject to the Reporting Person's continued service on such vesting date. All shares underlying the option will vest in full and become immediately exercisable upon a change of control of the Issuer or if the Reporting Person is terminated without cause or resigns for good reason. The option expires ten years after the date of grant. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units will vest and settle as to one third of the restricted stock units on January 30, 2026, and the remaining two thirds of the restricted stock units will vest and settle in equal annual installment thereafter, subject in each case to the Reporting Person's continued service through such vesting date. /s/ Timothy J. Sangiovanni, Attorney-in-Fact for Adrian W. Quartel 2025-03-27