X0508 4 2025-07-09 0 0001649904 RHYTHM PHARMACEUTICALS, INC. RYTM 0001909855 Shulman Joseph C/O RHYTHM PHARMACEUTICALS, INC. 222 BERKELEY STREET, 12TH FLOOR BOSTON MA 02116 0 1 0 0 Chief Technical Officer 1 Common Stock 2025-07-09 4 M 0 7969 6.8 A 16478 D Common Stock 2025-07-09 4 S 0 3984 75.5649 D 12494 D Common Stock 2025-07-09 4 S 0 3985 80 D 8509 D Stock Options (Right to Buy) 6.8 2025-07-09 4 M 0 7969 0 D 2032-02-08 Common Stock 7969 11953 D The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted on August 8, 2024. The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $75.12 to $75.92 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date. /s/ Stephen Vander Stoep, attorney-in-fact for Joseph Shulman 2025-07-11