X0508 4 2023-11-09 0001907685 Comera Life Sciences Holdings, Inc. CMRA 0001926535 Banerjee Sirshendu Roopom C/O COMERA LIFE SCIENCES HOLDINGS, INC. 12 GILL STREET, SUITE 4650 WOBURN MA 01801 1 0 0 0 0 Stock Option (Right to Purchase) 0.3204 2023-11-09 4 A 0 122487 0 A 2023-11-09 2033-11-09 Common Stock 122487 122487 D Granted pursuant to the Comera Life Sciences Holdings, Inc. 2022 Equity and Incentive Plan. The options were fully vested on the date of grant. In furtherance of the registrant's cash conservation efforts, the options were granted in lieu of the annual cash retainer and committee fees due to non-employee directors for the quarter ended September 30, 2023, in accordance with the registrant's February 2023 temporary modification to its non-employee director compensation plan. This option was issued to the reporting person in lieu of retainer fees of $16,250. For more information related to the registrant's non-employee director compensation plan and the February 2023 temporary modification, see the registrant's Annual Report on Form 10-K for the year ended December 31, 2022. /s/ Ryan M. Rourke Reed, Attorney-in-Fact 2023-11-14