X0508 4 2023-09-27 0001907685 Comera Life Sciences Holdings, Inc. CMRA 0001926254 Hackman Jeffrey S. C/O COMERA LIFE SCIENCES HOLDINGS, INC. 12 GILL STREET, SUITE 4650 WOBURN MA 01801 1 1 0 0 See Remarks. 0 Stock Option (Right to Purchase) 0.376 2023-09-27 4 A 0 600000 0 A 2033-09-27 Common Stock 600000 600000 D 25% of the shares underlying the stock option vest on September 27, 2024, with the remaining shares vesting on a monthly basis on the 27th day of each month thereafter, in each case, subject to continuous service to the issuer, such that the option shall be fully vested on September 27, 2027. Chairman, President, and Chief Executive Officer. /s/ Ryan M. Rourke Reed, Attorney-in-Fact 2023-09-28