X0206 3/A 2022-05-19 2022-05-20 0 0001907685 Comera Life Sciences Holdings, Inc. CMRA 0001926228 Muni Neal C/O COMERA LIFE SCIENCES HOLDINGS, INC. 12 GILL STREET, SUITE 4650 WOBURN MA 01801 0 1 0 0 See Remarks Stock Option (Right to Buy) 0.59 2031-09-16 Common Stock 208198 D This Form 3/A is being filed to correct information previously disclosed on the original Form 3 filed by the reporting person on May 20, 2022, including the Exercise Price, Amount or Number of Shares and vesting schedule of the stock option grant. This Form 3/A also includes the reporting person's power-of-attorney. This option was issued pursuant to the terms of a business combination agreement involving the issuer and Comera Life Sciences, Inc. in exchange for a comparable option previously issued by such company on September 16, 2021. 25% of the option vests or vested on the one year anniversary of the grant date and in equal monthly installments thereafter for 36 months. Executive Vice President and Chief Operating Officer. Exhibit 24 Power of Attorney filed herewith. /s/ Ryan M. Rourke Reed, Attorney-in-Fact 2023-02-14