X0306 4 2023-01-04 0001907685 Comera Life Sciences Holdings, Inc. CMRA 0001929093 Sullivan Edward Aloysius Jr. C/O COMERA LIFE SCIENCES HOLDINGS, INC. 12 GILL STREET, SUITE 4650 WOBURN MA 01801 1 0 0 0 Common Stock 2023-01-04 4 A 0 10979 1.23 A 19665 D Warrants (right to buy) 1.23 2023-01-04 4 A 0 10979 0.25 A 2023-01-04 2028-01-04 Common Stock 21958 10979 D The reporting person entered into a Securities Purchase Agreement with the Issuer on January 2, 2023, pursuant to which, on January 4, 2023, the reporting person acquired an aggregate of 10,979 units (the "Units") for a purchase price of $1.48 per Unit. Each Unit consists of one share of common stock, par value $0.0001 per share (the "Common Stock"), and one warrant (the "Warrants") to purchase two shares of Common Stock (the "Warrant Shares") at an exercise price of $1.23 per share. Each Warrant is immediately exercisable and expires five years from the date of issuance. The purchase price for each Unit includes $0.125 for each Warrant Share, or $0.25 per Warrant, in accordance with Nasdaq rules. The exercisability of the Warrants is subject to a 9.99% beneficial ownership limitation. /s/ Ryan M. Rourke Reed, Attorney-in-Fact 2023-01-06