X0306 4 2022-10-13 0001907685 Comera Life Sciences Holdings, Inc. CMRA 0001448698 Cherington Charles C/O ARA PARTNERS 5300 MEMORIAL DR., SUITE 500 HOUSTON TX 77077 0 0 1 0 Common Stock 2022-10-13 4 P 0 10481 1.6589 A 615411 D Common Stock 1268761 I By LLC Common Stock 95328 I By trust Common Stock 95327 I By trust Common Stock 95328 I By trust The price reported in Column 4 is a weighted-average price. These shares were purchased in multiple transactions at prices ranging from $1.58 to $1.70 inclusive. The report person undertakes to provide to Comera Life Sciences Holdings, Inc. ("Comera"), any security holder of Comera, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote 1. Held by Cherington Holdings LLC, of which the reporting person is a partner. Held by Ashley S. Pettus 2012 Irrevocable Trust FBO Benjamin P. Cherington, of which the reporting person is trustee. Held by Ashley S. Pettus 2012 Irrevocable Trust FBO Cyrus B. Cherington, of which the reporting person is trustee. Held by Ashley S. Pettus 2012 Irrevocable Trust FBO Henry S. Cherington, of which the reporting person is trustee. /s/ Megan Foscaldi, as attorney in fact for the Reporting Person 2022-10-14