X0306 4 2022-09-12 0001907685 Comera Life Sciences Holdings, Inc. CMRA 0001926230 Sherblom James C/O COMERA LIFE SCIENCES HOLDINGS, INC. 12 GILL STREET, SUITE 4650 WOBURN MA 01801 1 0 0 0 Common Stock 2022-09-12 4 P 0 50000 2.03 A 371163 D The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.93 to $2.07, inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth herein. Exhibit 24 Power of Attorney filed herewith. /s/ Ryan M. Rourke Reed, Attorney-in-Fact 2022-09-12