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Transaction and Reverse Recapitalization - Summary of Common Stock Issued and Outstanding (Details) - shares
Dec. 31, 2022
Dec. 31, 2021
Subsidiary, Sale of Stock [Line Items]    
Common stock, shares issued 16,709,221 308,443
Common stock, shares outstanding 16,709,221 308,443
CLS Holdings [Member]    
Subsidiary, Sale of Stock [Line Items]    
Common stock, shares outstanding 15,937,185  
Ownership percentage 100.00%  
Legacy Comera Stockholders | CLS Holdings [Member]    
Subsidiary, Sale of Stock [Line Items]    
Common stock, shares issued 12,022,595  
Ownership percentage 76.00%  
OTR Public Stockholders | CLS Holdings [Member]    
Subsidiary, Sale of Stock [Line Items]    
Common stock, shares outstanding 677,987  
Ownership percentage 4.00%  
OTR Founders | CLS Holdings [Member]    
Subsidiary, Sale of Stock [Line Items]    
Common stock, shares outstanding 2,611,838  
Ownership percentage 16.00%  
Maxim Group LLC. | CLS Holdings [Member]    
Subsidiary, Sale of Stock [Line Items]    
Common stock, shares outstanding 624,765  
Ownership percentage 4.00%