X0306 4 2023-01-04 0 0001907685 Comera Life Sciences Holdings, Inc. CMRA 0001448698 Cherington Charles C/O ARA PARTNERS 5300 MEMORIAL DR., SUITE 500 HOUSTON TX 77077 0 0 1 0 Common Stock 2023-01-04 4 P 0 743243 1.23 A 2879666 D Common Stock 1268761 I By LLC Common Stock 95328 I By trust Common Stock 95327 I By trust Common Stock 95328 I By trust Warrants to Purchase Common Stock 1.23 2023-01-04 4 P 0 743243 0.25 A 2023-01-04 2028-01-04 Common Stock 1486486 743243 D On January 4, 2023, pursuant to a private placement offering by the Issuer, the Reporting Person acquired 743,243 Units, each Unit consisting of (i) one share of the Issuer's Common Stock and (ii) one Warrant to purchase two shares of Common Stock. The combined purchase price in the Offering was $1.48 per Unit, inclusive of $1.23 per share of Common Stock and $0.25 per Warrant. Held by Cherington Holdings LLC, of which the reporting person is a partner. Held by Ashley S. Pettus 2012 Irrevocable Trust FBO Benjamin P. Cherington, of which the reporting person is trustee. Held by Ashley S. Pettus 2012 Irrevocable Trust FBO Cyrus B. Cherington, of which the reporting person is trustee. Held by Ashley S. Pettus 2012 Irrevocable Trust FBO Henry S. Cherington, of which the reporting person is trustee. /s/ Charles Cherington 2023-01-06