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                          September 1, 2023

       Jeffrey S. Hackman
       Chief Executive Officer
       Comera Life Sciences Holdings, Inc.
       12 Gill Street, Suite 4650
       Woburn, MA 01801

                                                        Re: Comera Life
Sciences Holdings, Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed August 29,
2023
                                                            File No. 333-274253

       Dear Jeffrey S. Hackman:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Tyler
Howes at 202-551-3370 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Ryan M. Rourke Reed,
Esq.