The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
NVIDIA CORP Common Stock 67066G104   86,243,825 462,213 SH   SOLE   462,213 0 0
MICROSOFT CORP Common Stock 594918104   75,658,510 146,073 SH   SOLE   146,073 0 0
APPLE INC Common Stock 037833100   64,063,635 251,595 SH   SOLE   251,595 0 0
AMAZON.COM INC Common Stock 023135106   53,514,040 243,722 SH   SOLE   243,722 0 0
BROADCOM INC Common Stock 11135F101   48,616,527 147,363 SH   SOLE   147,363 0 0
ALPHABET INC-CL A Common Stock 02079K305   36,963,355 152,050 SH   SOLE   152,050 0 0
META PLATFORMS INC-CLASS A Common Stock 30303M102   35,877,401 48,854 SH   SOLE   48,854 0 0
NETFLIX INC Common Stock 64110L106   23,857,309 19,899 SH   SOLE   19,899 0 0
TESLA INC Common Stock 88160R101   21,570,699 48,504 SH   SOLE   48,504 0 0
AMGEN INC Common Stock 031162100   18,238,022 64,628 SH   SOLE   64,628 0 0
GILEAD SCIENCES INC Common Stock 375558103   17,888,205 161,155 SH   SOLE   161,155 0 0
VERTEX PHARMACEUTICALS INC Common Stock 92532F100   17,668,447 45,114 SH   SOLE   45,114 0 0
ALPHABET INC-CL C Common Stock 02079K107   17,242,853 70,798 SH   SOLE   70,798 0 0
PALANTIR TECHNOLOGIES INC-A Common Stock 69608A108   15,453,710 84,715 SH   SOLE   84,715 0 0
APPLOVIN CORP-CLASS A Common Stock 03831W108   14,817,013 20,621 SH   SOLE   20,621 0 0
ISHARES GOLD TRUST MICRO ETP 46436F103   14,726,250 382,500 SH   SOLE   382,500 0 0
COSTCO WHOLESALE CORP Common Stock 22160K105   14,642,541 15,819 SH   SOLE   15,819 0 0
SPDR GOLD MINISHARES TRUST ETP 98149E303   14,464,340 189,200 SH   SOLE   189,200 0 0
REGENERON PHARMACEUTICALS Common Stock 75886F107   12,009,525 21,359 SH   SOLE   21,359 0 0
GRANITESHARES GOLD TRUST ETP 38748G101   11,532,180 303,000 SH   SOLE   303,000 0 0
VISA INC-CLASS A SHARES Common Stock 92826C839   10,639,108 31,165 SH   SOLE   31,165 0 0
ALNYLAM PHARMACEUTICALS INC Common Stock 02043Q107   10,390,872 22,787 SH   SOLE   22,787 0 0
ASTRAZENECA PLC-SPONS ADR ADR 046353108   10,248,258 133,580 SH   SOLE   133,580 0 0
ADVANCED MICRO DEVICES Common Stock 007903107   10,075,958 62,278 SH   SOLE   62,278 0 0
SPDR GOLD SHARES ETP 78463V107   9,833,011 27,662 SH   SOLE   27,662 0 0
GOLDMAN SACHS PHYSICAL GOLD ETP 38150K103   8,843,840 232,000 SH   SOLE   232,000 0 0
KLA CORP Common Stock 482480100   8,751,760 8,114 SH   SOLE   8,114 0 0
INTUIT INC Common Stock 461202103   8,724,858 12,776 SH   SOLE   12,776 0 0
CISCO SYSTEMS INC Common Stock 17275R102   7,847,090 114,690 SH   SOLE   114,690 0 0
SHOPIFY INC - CLASS A Common Stock 82509L107   7,715,534 51,918 SH   SOLE   51,918 0 0
ISHARES SILVER TRUST ETP 46428Q109   7,537,623 177,900 SH   SOLE   177,900 0 0
PALO ALTO NETWORKS INC Common Stock 697435105   7,423,578 36,458 SH   SOLE   36,458 0 0
ANALOG DEVICES INC Common Stock 032654105   7,330,951 29,837 SH   SOLE   29,837 0 0
BOOKING HOLDINGS INC Common Stock 09857L108   7,321,410 1,356 SH   SOLE   1,356 0 0
TAIWAN SEMICONDUCTOR-SP ADR ADR 874039100   7,217,830 25,784 SH   SOLE   25,784 0 0
T-MOBILE US INC Common Stock 872590104   7,111,980 29,710 SH   SOLE   29,710 0 0
LAM RESEARCH CORP Common Stock 512807306   6,694,255 49,911 SH   SOLE   49,911 0 0
MICRON TECHNOLOGY INC Common Stock 595112103   6,616,502 39,544 SH   SOLE   39,544 0 0
LINDE PLC Common Stock G54950103   6,450,500 13,580 SH   SOLE   13,580 0 0
AMPHENOL CORP-CL A Common Stock 032095101   5,947,128 48,000 SH   SOLE   48,000 0 0
ORACLE CORP Common Stock 68389X105   5,884,103 20,922 SH   SOLE   20,922 0 0
BRITISH AMERICAN TOB-SP ADR ADR 110448107   5,677,331 106,958 SH   SOLE   106,958 0 0
PEPSICO INC Common Stock 713448108   5,567,042 39,640 SH   SOLE   39,640 0 0
SYNOPSYS INC Common Stock 871607107   5,543,237 11,235 SH   SOLE   11,235 0 0
DOORDASH INC - A Common Stock 25809K105   5,540,980 20,372 SH   SOLE   20,372 0 0
ALIBABA GROUP HOLDING-SP ADR ADR 01609W102   5,526,868 30,923 SH   SOLE   30,923 0 0
ABRDN PHYSICAL GOLD SHARES ETP 00326A104   5,374,260 146,000 SH   SOLE   146,000 0 0
INSMED INC Common Stock 457669307   5,335,715 37,051 SH   SOLE   37,051 0 0
INTEL CORP Common Stock 458140100   5,151,569 153,549 SH   SOLE   153,549 0 0
MASTERCARD INC - A Common Stock 57636Q104   5,150,006 9,054 SH   SOLE   9,054 0 0
INTUITIVE SURGICAL INC Common Stock 46120E602   5,126,597 11,463 SH   SOLE   11,463 0 0
MERCADOLIBRE INC Common Stock 58733R102   5,089,855 2,178 SH   SOLE   2,178 0 0
QUALCOMM INC Common Stock 747525103   5,071,485 30,485 SH   SOLE   30,485 0 0
ADOBE INC Common Stock 00724F101   4,797,047 13,599 SH   SOLE   13,599 0 0
HOME DEPOT INC Common Stock 437076102   4,630,511 11,428 SH   SOLE   11,428 0 0
TEXAS INSTRUMENTS INC Common Stock 882508104   4,409,520 24,000 SH   SOLE   24,000 0 0
SEA LTD-ADR ADR 81141R100   4,361,012 24,400 SH   SOLE   24,400 0 0
CROWDSTRIKE HOLDINGS INC - A Common Stock 22788C105   4,327,604 8,825 SH   SOLE   8,825 0 0
ELI LILLY & CO Common Stock 532457108   4,314,765 5,655 SH   SOLE   5,655 0 0
APPLIED MATERIALS INC Common Stock 038222105   4,305,887 21,031 SH   SOLE   21,031 0 0
UNITED THERAPEUTICS CORP Common Stock 91307C102   4,161,498 9,927 SH   SOLE   9,927 0 0
BIOGEN INC Common Stock 09062X103   4,142,166 29,570 SH   SOLE   29,570 0 0
NETEASE INC-ADR ADR 64110W102   3,966,939 26,100 SH   SOLE   26,100 0 0
ARGENX SE - ADR ADR 04016X101   3,957,747 5,366 SH   SOLE   5,366 0 0
PDD HOLDINGS INC ADR 722304102   3,747,945 28,357 SH   SOLE   28,357 0 0
CADENCE DESIGN SYS INC Common Stock 127387108   3,721,248 10,594 SH   SOLE   10,594 0 0
UBER TECHNOLOGIES INC Common Stock 90353T100   3,651,146 37,268 SH   SOLE   37,268 0 0
PROSHARES ULTRA GOLD ETP 74347W601   3,583,468 77,800 SH   SOLE   77,800 0 0
SERVICENOW INC Common Stock 81762P102   3,578,049 3,888 SH   SOLE   3,888 0 0
HONEYWELL INTERNATIONAL INC Common Stock 438516106   3,528,191 16,761 SH   SOLE   16,761 0 0
FULL TRUCK ALLIANCE -SPN ADR ADR 35969L108   3,462,990 267,000 SH   SOLE   267,000 0 0
JOHNSON & JOHNSON Common Stock 478160104   3,455,858 18,638 SH   SOLE   18,638 0 0
FUTU HOLDINGS LTD-ADR ADR 36118L106   3,439,244 19,776 SH   SOLE   19,776 0 0
ISHARES GOLD TRUST ETP 464285204   3,347,420 46,000 SH   SOLE   46,000 0 0
SANOFI-ADR ADR 80105N105   3,239,478 68,633 SH   SOLE   68,633 0 0
AUTOMATIC DATA PROCESSING Common Stock 053015103   3,153,174 10,693 SH   SOLE   10,693 0 0
AUTODESK INC Common Stock 052769106   3,128,732 9,849 SH   SOLE   9,849 0 0
BOSTON SCIENTIFIC CORP Common Stock 101137107   3,124,160 32,000 SH   SOLE   32,000 0 0
CELESTICA INC Common Stock 15101Q207   3,055,112 12,400 SH   SOLE   12,400 0 0
COMCAST CORP-CLASS A Common Stock 20030N101   3,054,715 97,222 SH   SOLE   97,222 0 0
INCYTE CORP Common Stock 45337C102   2,902,961 34,229 SH   SOLE   34,229 0 0
ROYAL CARIBBEAN CRUISES LTD Common Stock V7780T103   2,720,865 8,399 SH   SOLE   8,399 0 0
CONSTELLATION ENERGY Common Stock 21037T109   2,713,840 8,247 SH   SOLE   8,247 0 0
SUMMIT THERAPEUTICS INC Common Stock 86627T108   2,690,139 130,210 SH   SOLE   130,210 0 0
NIKE INC -CL B Common Stock 654106103   2,679,120 38,366 SH   SOLE   38,366 0 0
ROYALTY PHARMA PLC- CL A Common Stock G7709Q104   2,673,342 75,775 SH   SOLE   75,775 0 0
MERCK & CO. INC. Common Stock 58933Y105   2,658,801 31,406 SH   SOLE   31,406 0 0
FORTINET INC Common Stock 34959E109   2,625,734 31,229 SH   SOLE   31,229 0 0
TRIP.COM GROUP LTD-ADR ADR 89677Q107   2,594,400 34,500 SH   SOLE   34,500 0 0
NOVARTIS AG-SPONSORED ADR ADR 66987V109   2,564,800 20,000 SH   SOLE   20,000 0 0
STARBUCKS CORP Common Stock 855244109   2,546,798 30,104 SH   SOLE   30,104 0 0
MEDPACE HOLDINGS INC Common Stock 58506Q109   2,531,724 4,924 SH   SOLE   4,924 0 0
ABBVIE INC Common Stock 00287Y109   2,525,175 10,906 SH   SOLE   10,906 0 0
ATRENEW INC ADR 00138L108   2,465,600 536,000 SH   SOLE   536,000 0 0
ASML HOLDING NV-NY REG SHS NY Reg Shrs N07059210   2,456,044 2,537 SH   SOLE   2,537 0 0
NEUROCRINE BIOSCIENCES INC Common Stock 64125C109   2,440,506 17,385 SH   SOLE   17,385 0 0
TENET HEALTHCARE CORP Common Stock 88033G407   2,436,480 12,000 SH   SOLE   12,000 0 0
O'REILLY AUTOMOTIVE INC Common Stock 67103H107   2,414,944 22,400 SH   SOLE   22,400 0 0
WORKDAY INC-CLASS A Common Stock 98138H101   2,402,245 9,979 SH   SOLE   9,979 0 0
TEMPUS AI INC Common Stock 88023B103   2,386,433 29,568 SH   SOLE   29,568 0 0
SAP SE-SPONSORED ADR ADR 803054204   2,298,006 8,600 SH   SOLE   8,600 0 0
TENCENT MUSIC ENTERTAINM-ADR ADR 88034P109   2,287,320 98,000 SH   SOLE   98,000 0 0
ROBLOX CORP -CLASS A Common Stock 771049103   2,285,580 16,500 SH   SOLE   16,500 0 0
STRATEGY INC Common Stock 594972408   2,244,837 6,967 SH   SOLE   6,967 0 0
JPMORGAN CHASE & CO Common Stock 46625H100   2,236,399 7,090 SH   SOLE   7,090 0 0
CINTAS CORP Common Stock 172908105   2,183,556 10,638 SH   SOLE   10,638 0 0
MONDELEZ INTERNATIONAL INC-A Common Stock 609207105   2,149,272 34,159 SH   SOLE   34,159 0 0
ASCENDIS PHARMA A/S - ADR ADR 04351P101   2,120,706 10,667 SH   SOLE   10,667 0 0
VIATRIS INC Common Stock 92556V106   2,023,164 204,360 SH   SOLE   204,360 0 0
ZSCALER INC Common Stock 98980G102   2,010,719 6,710 SH   SOLE   6,710 0 0
BEONE MEDICINES LTD-ADR ADR 07725L102   2,007,404 5,892 SH   SOLE   5,892 0 0
REVOLUTION MEDICINES INC Common Stock 76155X100   1,997,219 42,767 SH   SOLE   42,767 0 0
ASTERA LABS INC Common Stock 04626A103   1,997,160 10,200 SH   SOLE   10,200 0 0
EXELIXIS INC Common Stock 30161Q104   1,948,823 47,187 SH   SOLE   47,187 0 0
THERMO FISHER SCIENTIFIC INC Common Stock 883556102   1,923,668 3,963 SH   SOLE   3,963 0 0
MARVELL TECHNOLOGY INC Common Stock 573874104   1,913,349 22,759 SH   SOLE   22,759 0 0
MARRIOTT INTERNATIONAL -CL A Common Stock 571903202   1,866,313 7,166 SH   SOLE   7,166 0 0
CREDO TECHNOLOGY GROUP HOLDI Common Stock G25457105   1,863,808 12,800 SH   SOLE   12,800 0 0
THOMSON REUTERS CORP Common Stock 884903808   1,848,116 11,898 SH   SOLE   11,898 0 0
IONIS PHARMACEUTICALS INC Common Stock 462222100   1,827,769 27,939 SH   SOLE   27,939 0 0
BIOMARIN PHARMACEUTICAL INC Common Stock 09061G101   1,822,863 33,657 SH   SOLE   33,657 0 0
ROIVANT SCIENCES LTD Common Stock G76279101   1,811,046 119,699 SH   SOLE   119,699 0 0
MADRIGAL PHARMACEUTICALS INC Common Stock 558868105   1,791,985 3,907 SH   SOLE   3,907 0 0
MODERNA INC Common Stock 60770K107   1,761,606 68,200 SH   SOLE   68,200 0 0
CVS HEALTH CORP Common Stock 126650100   1,756,587 23,300 SH   SOLE   23,300 0 0
CSX CORP Common Stock 126408103   1,747,625 49,215 SH   SOLE   49,215 0 0
BRIDGEBIO PHARMA INC Common Stock 10806X102   1,740,457 33,509 SH   SOLE   33,509 0 0
BIONTECH SE-ADR ADR 09075V102   1,739,065 17,634 SH   SOLE   17,634 0 0
BERKSHIRE HATHAWAY INC-CL B Common Stock 084670702   1,737,972 3,457 SH   SOLE   3,457 0 0
MONSTER BEVERAGE CORP Common Stock 61174X109   1,735,050 25,777 SH   SOLE   25,777 0 0
PAYPAL HOLDINGS INC Common Stock 70450Y103   1,691,320 25,221 SH   SOLE   25,221 0 0
AMERICAN ELECTRIC POWER Common Stock 025537101   1,588,275 14,118 SH   SOLE   14,118 0 0
VERONA PHARMA PLC - ADR ADR 925050106   1,583,363 14,838 SH   SOLE   14,838 0 0
NXP SEMICONDUCTORS NV Common Stock N6596X109   1,521,478 6,656 SH   SOLE   6,656 0 0
HALOZYME THERAPEUTICS INC Common Stock 40637H109   1,503,617 20,502 SH   SOLE   20,502 0 0
AXON ENTERPRISE INC Common Stock 05464C101   1,486,950 2,072 SH   SOLE   2,072 0 0
FASTENAL CO Common Stock 311900104   1,485,765 30,297 SH   SOLE   30,297 0 0
ARROWHEAD PHARMACEUTICALS IN Common Stock 04280A100   1,456,651 42,234 SH   SOLE   42,234 0 0
ROPER TECHNOLOGIES INC Common Stock 776696106   1,416,778 2,841 SH   SOLE   2,841 0 0
JAZZ PHARMACEUTICALS PLC Common Stock G50871105   1,401,429 10,633 SH   SOLE   10,633 0 0
LUMENTUM HOLDINGS INC Common Stock 55024U109   1,383,035 8,500 SH   SOLE   8,500 0 0
TTM TECHNOLOGIES Common Stock 87305R109   1,382,400 24,000 SH   SOLE   24,000 0 0
PROCTER & GAMBLE CO/THE Common Stock 742718109   1,380,545 8,985 SH   SOLE   8,985 0 0
AIRBNB INC-CLASS A Common Stock 009066101   1,375,324 11,327 SH   SOLE   11,327 0 0
GUARDANT HEALTH INC Common Stock 40131M109   1,365,750 21,859 SH   SOLE   21,859 0 0
PACCAR INC Common Stock 693718108   1,362,912 13,862 SH   SOLE   13,862 0 0
UNITEDHEALTH GROUP INC Common Stock 91324P102   1,351,504 3,914 SH   SOLE   3,914 0 0
IDEXX LABORATORIES INC Common Stock 45168D104   1,349,336 2,112 SH   SOLE   2,112 0 0
ELECTRONIC ARTS INC Common Stock 285512109   1,332,229 6,605 SH   SOLE   6,605 0 0
ROSS STORES INC Common Stock 778296103   1,318,864 8,634 SH   SOLE   8,634 0 0
WARNER BROS DISCOVERY INC Common Stock 934423104   1,276,442 65,358 SH   SOLE   65,358 0 0
KYMERA THERAPEUTICS INC Common Stock 501575104   1,275,311 22,532 SH   SOLE   22,532 0 0
BAKER HUGHES CO Common Stock 05722G100   1,267,987 26,026 SH   SOLE   26,026 0 0
XCEL ENERGY INC Common Stock 98389B100   1,266,977 15,613 SH   SOLE   15,613 0 0
AMER SPORTS INC Common Stock G0260P102   1,262,363 36,327 SH   SOLE   36,327 0 0
TAKE-TWO INTERACTIVE SOFTWRE Common Stock 874054109   1,258,213 4,870 SH   SOLE   4,870 0 0
COHERENT CORP Common Stock 19247G107   1,249,552 11,600 SH   SOLE   11,600 0 0
MERUS NV Common Stock N5749R100   1,248,241 13,258 SH   SOLE   13,258 0 0
LOWE'S COS INC Common Stock 548661107   1,240,717 4,937 SH   SOLE   4,937 0 0
SNOWFLAKE INC Common Stock 833445109   1,240,525 5,500 SH   SOLE   5,500 0 0
EXXON MOBIL CORP Common Stock 30231G102   1,239,574 10,994 SH   SOLE   10,994 0 0
SPOTIFY TECHNOLOGY SA Common Stock L8681T102   1,221,500 1,750 SH   SOLE   1,750 0 0
DATADOG INC - CLASS A Common Stock 23804L103   1,215,242 8,534 SH   SOLE   8,534 0 0
PAYCHEX INC Common Stock 704326107   1,203,333 9,493 SH   SOLE   9,493 0 0
EXELON CORP Common Stock 30161N101   1,200,102 26,663 SH   SOLE   26,663 0 0
MCKESSON CORP Common Stock 58155Q103   1,197,034 1,548 SH   SOLE   1,548 0 0
RHYTHM PHARMACEUTICALS INC Common Stock 76243J105   1,175,726 11,642 SH   SOLE   11,642 0 0
WALMART INC Common Stock 931142103   1,153,963 11,197 SH   SOLE   11,197 0 0
CYTOKINETICS INC Common Stock 23282W605   1,152,731 20,974 SH   SOLE   20,974 0 0
COPART INC Common Stock 217204106   1,147,904 25,526 SH   SOLE   25,526 0 0
ATLASSIAN CORP-CL A Common Stock 049468101   1,132,273 7,090 SH   SOLE   7,090 0 0
COCA-COLA EUROPACIFIC PARTNE Common Stock G25839104   1,093,599 12,096 SH   SOLE   12,096 0 0
DIAMONDBACK ENERGY INC Common Stock 25278X109   1,093,570 7,642 SH   SOLE   7,642 0 0
MONDAY.COM LTD Common Stock M7S64H106   1,065,295 5,500 SH   SOLE   5,500 0 0
AXSOME THERAPEUTICS INC Common Stock 05464T104   1,062,323 8,747 SH   SOLE   8,747 0 0
PROTAGONIST THERAPEUTICS INC Common Stock 74366E102   1,056,569 15,905 SH   SOLE   15,905 0 0
CRISPR THERAPEUTICS AG Common Stock H17182108   1,033,201 15,942 SH   SOLE   15,942 0 0
MCDONALD'S CORP Common Stock 580135101   1,015,904 3,343 SH   SOLE   3,343 0 0
NUVALENT INC-A Common Stock 670703107   1,010,605 11,686 SH   SOLE   11,686 0 0
CHARTER COMMUNICATIONS INC-A Common Stock 16119P108   992,029 3,606 SH   SOLE   3,606 0 0
AVIDITY BIOSCIENCES INC Common Stock 05370A108   982,547 22,551 SH   SOLE   22,551 0 0
ELEVANCE HEALTH INC Common Stock 036752103   969,360 3,000 SH   SOLE   3,000 0 0
COSTAR GROUP INC Common Stock 22160N109   943,594 11,184 SH   SOLE   11,184 0 0
BANK OF AMERICA CORP Common Stock 060505104   941,672 18,253 SH   SOLE   18,253 0 0
VERISK ANALYTICS INC Common Stock 92345Y106   927,569 3,688 SH   SOLE   3,688 0 0
KEURIG DR PEPPER INC Common Stock 49271V100   922,247 35,862 SH   SOLE   35,862 0 0
MICROCHIP TECHNOLOGY INC Common Stock 595017104   914,942 14,247 SH   SOLE   14,247 0 0
GE HEALTHCARE TECHNOLOGY Common Stock 36266G107   905,180 12,053 SH   SOLE   12,053 0 0
KRYSTAL BIOTECH INC Common Stock 501147102   895,537 5,073 SH   SOLE   5,073 0 0
ALKERMES PLC Common Stock G01767105   868,080 28,936 SH   SOLE   28,936 0 0
COGNIZANT TECH SOLUTIONS-A Common Stock 192446102   864,734 12,893 SH   SOLE   12,893 0 0
PTC THERAPEUTICS INC Common Stock 69366J200   854,516 13,924 SH   SOLE   13,924 0 0
RAMBUS INC Common Stock 750917106   833,600 8,000 SH   SOLE   8,000 0 0
VAXCYTE INC Common Stock 92243G108   819,671 22,756 SH   SOLE   22,756 0 0
GENERAL ELECTRIC Common Stock 369604301   819,112 2,720 SH   SOLE   2,720 0 0
KRAFT HEINZ CO/THE Common Stock 500754106   813,646 31,246 SH   SOLE   31,246 0 0
ARISTA NETWORKS INC Common Stock 040413205   801,405 5,500 SH   SOLE   5,500 0 0
ARCELLX INC Common Stock 03940C100   798,094 9,721 SH   SOLE   9,721 0 0
DUOLINGO Common Stock 26603R106   784,968 2,439 SH   SOLE   2,439 0 0
OLD DOMINION FREIGHT LINE Common Stock 679580100   781,047 5,548 SH   SOLE   5,548 0 0
CHEVRON CORP Common Stock 166764100   776,605 5,001 SH   SOLE   5,001 0 0
LI AUTO INC - ADR ADR 50202M102   760,200 30,000 SH   SOLE   30,000 0 0
STRYKER CORP Common Stock 863667101   740,852 2,000 SH   SOLE   2,000 0 0
CONSUMER DISCRETIONARY SELT ETP 81369Y407   722,515 3,015 SH   SOLE   3,015 0 0
TJX COMPANIES INC Common Stock 872540109   718,364 4,970 SH   SOLE   4,970 0 0
JOYY INC-ADR ADR 46591M109   714,660 12,000 SH   SOLE   12,000 0 0
OCULAR THERAPEUTIX INC Common Stock 67576A100   707,233 60,499 SH   SOLE   60,499 0 0
RUBRIK INC-A Common Stock 781154109   699,125 8,500 SH   SOLE   8,500 0 0
DEXCOM INC Common Stock 252131107   696,653 10,353 SH   SOLE   10,353 0 0
COCA-COLA CO/THE Common Stock 191216100   696,572 10,431 SH   SOLE   10,431 0 0
WELLS FARGO & CO Common Stock 949746101   688,581 8,215 SH   SOLE   8,215 0 0
CRINETICS PHARMACEUTICALS IN Common Stock 22663K107   687,558 16,508 SH   SOLE   16,508 0 0
INTELLIA THERAPEUTICS INC Common Stock 45826J105   670,352 38,816 SH   SOLE   38,816 0 0
INTL BUSINESS MACHINES CORP Common Stock 459200101   669,001 2,371 SH   SOLE   2,371 0 0
REPLIGEN CORP Common Stock 759916109   668,350 5,000 SH   SOLE   5,000 0 0
AKERO THERAPEUTICS INC Common Stock 00973Y108   665,717 14,021 SH   SOLE   14,021 0 0
ON SEMICONDUCTOR Common Stock 682189105   655,675 13,297 SH   SOLE   13,297 0 0
MIRUM PHARMACEUTICALS INC Common Stock 604749101   645,568 8,806 SH   SOLE   8,806 0 0
PHILIP MORRIS INTERNATIONAL Common Stock 718172109   644,096 3,971 SH   SOLE   3,971 0 0
SUPERNUS PHARMACEUTICALS INC Common Stock 868459108   641,772 13,429 SH   SOLE   13,429 0 0
ACADIA PHARMACEUTICALS INC Common Stock 004225108   631,088 29,573 SH   SOLE   29,573 0 0
SCHOLAR ROCK HOLDING CORP Common Stock 80706P103   627,494 16,850 SH   SOLE   16,850 0 0
BEAM THERAPEUTICS INC Common Stock 07373V105   624,516 25,732 SH   SOLE   25,732 0 0
GOLDMAN SACHS GROUP INC Common Stock 38141G104   623,542 783 SH   SOLE   783 0 0
ADMA BIOLOGICS INC Common Stock 000899104   613,198 41,828 SH   SOLE   41,828 0 0
LIGAND PHARMACEUTICALS Common Stock 53220K504   608,476 3,435 SH   SOLE   3,435 0 0
ABBOTT LABORATORIES Common Stock 002824100   594,426 4,438 SH   SOLE   4,438 0 0
SALESFORCE INC Common Stock 79466L302   578,956 2,439 SH   SOLE   2,439 0 0
TRADE DESK INC/THE -CLASS A Common Stock 88339J105   576,603 11,765 SH   SOLE   11,765 0 0
CATERPILLAR INC Common Stock 149123101   572,580 1,200 SH   SOLE   1,200 0 0
RTX CORP Common Stock 75513E101   570,261 3,408 SH   SOLE   3,408 0 0
WAVE LIFE SCIENCES LTD Common Stock Y95308105   570,191 77,895 SH   SOLE   77,895 0 0
HESAI GROUP ADR 428050108   562,000 20,000 SH   SOLE   20,000 0 0
NEWAMSTERDAM PHARMA CO NV Common Stock N62509109   561,462 19,742 SH   SOLE   19,742 0 0
UNIQURE NV Common Stock N90064101   561,344 9,617 SH   SOLE   9,617 0 0
CDW CORP/DE Common Stock 12514G108   551,109 3,460 SH   SOLE   3,460 0 0
AMNEAL PHARMACEUTICALS INC Common Stock 03168L105   551,081 55,053 SH   SOLE   55,053 0 0
XENON PHARMACEUTICALS INC Common Stock 98420N105   542,627 13,515 SH   SOLE   13,515 0 0
LULULEMON ATHLETICA INC Common Stock 550021109   538,950 3,029 SH   SOLE   3,029 0 0
CG ONCOLOGY INC Common Stock 156944100   538,342 13,365 SH   SOLE   13,365 0 0
INDIVIOR PLC Common Stock G4766E116   527,286 21,870 SH   SOLE   21,870 0 0
WALT DISNEY CO/THE Common Stock 254687106   525,097 4,586 SH   SOLE   4,586 0 0
GLOBALFOUNDRIES INC Common Stock G39387108   525,092 14,651 SH   SOLE   14,651 0 0
GRAIL INC Common Stock 384747101   521,467 8,819 SH   SOLE   8,819 0 0
AT&T INC Common Stock 00206R102   518,373 18,356 SH   SOLE   18,356 0 0
ARM HOLDINGS PLC-ADR ADR 042068205   510,213 3,606 SH   SOLE   3,606 0 0
ULTRAGENYX PHARMACEUTICAL IN Common Stock 90400D108   508,141 16,893 SH   SOLE   16,893 0 0
FERRARI NV Common Stock N3167Y103   504,144 1,039 SH   SOLE   1,039 0 0
APELLIS PHARMACEUTICALS INC Common Stock 03753U106   500,960 22,137 SH   SOLE   22,137 0 0
SPDR S&P BIOTECH ETF ETP 78464A870   492,884 4,919 SH   SOLE   4,919 0 0
IMMUNOVANT INC Common Stock 45258J102   492,547 30,555 SH   SOLE   30,555 0 0
LEGEND BIOTECH CORP-ADR ADR 52490G102   481,291 14,759 SH   SOLE   14,759 0 0
VERACYTE INC Common Stock 92337F107   473,411 13,790 SH   SOLE   13,790 0 0
VERIZON COMMUNICATIONS INC Common Stock 92343V104   472,726 10,756 SH   SOLE   10,756 0 0
DISC MEDICINE INC Common Stock 254604101   468,772 7,094 SH   SOLE   7,094 0 0
ADAPTIVE BIOTECHNOLOGIES Common Stock 00650F109   453,153 30,291 SH   SOLE   30,291 0 0
BRISTOL-MYERS SQUIBB CO Common Stock 110122108   451,000 10,000 SH   SOLE   10,000 0 0
ALVOTECH SA Common Stock L01800108   449,369 54,868 SH   SOLE   54,868 0 0
MINERALYS THERAPEUTICS INC Common Stock 603170101   440,668 11,621 SH   SOLE   11,621 0 0
TARSUS PHARMACEUTICALS INC Common Stock 87650L103   439,782 7,400 SH   SOLE   7,400 0 0
ZETA GLOBAL HOLDINGS CORP-A Common Stock 98956A105   437,140 22,000 SH   SOLE   22,000 0 0
AUTOZONE INC Common Stock 053332102   429,024 100 SH   SOLE   100 0 0
AMICUS THERAPEUTICS INC Common Stock 03152W109   425,756 54,030 SH   SOLE   54,030 0 0
IDEAYA BIOSCIENCES INC Common Stock 45166A102   418,027 15,363 SH   SOLE   15,363 0 0
AGIOS PHARMACEUTICALS INC Common Stock 00847X104   408,786 10,184 SH   SOLE   10,184 0 0
CENTESSA PHARMACEUTICALS-ADR ADR 152309100   407,788 16,816 SH   SOLE   16,816 0 0
IMMUNITYBIO INC Common Stock 45256X103   407,595 165,689 SH   SOLE   165,689 0 0
KANZHUN LTD - ADR ADR 48553T106   404,128 17,300 SH   SOLE   17,300 0 0
H WORLD GROUP LTD-ADR ADR 44332N106   398,922 10,200 SH   SOLE   10,200 0 0
ARCUTIS BIOTHERAPEUTICS INC Common Stock 03969K108   396,189 21,018 SH   SOLE   21,018 0 0
DECKERS OUTDOOR CORP Common Stock 243537107   396,154 3,908 SH   SOLE   3,908 0 0
DIAGEO PLC-SPONSORED ADR ADR 25243Q205   392,885 4,117 SH   SOLE   4,117 0 0
89BIO INC Common Stock 282559103   382,141 25,996 SH   SOLE   25,996 0 0
TRAVERE THERAPEUTICS INC Common Stock 89422G107   373,438 15,625 SH   SOLE   15,625 0 0
LENZ THERAPEUTICS INC Common Stock 52635N103   372,593 7,999 SH   SOLE   7,999 0 0
DENALI THERAPEUTICS INC Common Stock 24823R105   372,133 25,629 SH   SOLE   25,629 0 0
BELITE BIO INC - ADR ADR 07782B104   370,000 5,000 SH   SOLE   5,000 0 0
RECURSION PHARMACEUTICALS-A Common Stock 75629V104   365,522 74,902 SH   SOLE   74,902 0 0
VF CORP Common Stock 918204108   359,394 24,906 SH   SOLE   24,906 0 0
COGENT BIOSCIENCES INC Common Stock 19240Q201   351,633 24,487 SH   SOLE   24,487 0 0
ANI PHARMACEUTICALS INC Common Stock 00182C103   348,263 3,802 SH   SOLE   3,802 0 0
SAREPTA THERAPEUTICS INC Common Stock 803607100   330,057 17,128 SH   SOLE   17,128 0 0
VERA THERAPEUTICS INC Common Stock 92337R101   325,094 11,187 SH   SOLE   11,187 0 0
ORIC PHARMACEUTICALS INC Common Stock 68622P109   324,288 27,024 SH   SOLE   27,024 0 0
NATERA INC Common Stock 632307104   321,940 2,000 SH   SOLE   2,000 0 0
APOGEE THERAPEUTICS INC Common Stock 03770N101   321,098 8,082 SH   SOLE   8,082 0 0
DYNE THERAPEUTICS INC Common Stock 26818M108   315,453 24,937 SH   SOLE   24,937 0 0
EYEPOINT PHARMACEUTICALS INC Common Stock 30233G209   314,448 22,082 SH   SOLE   22,082 0 0
HARROW INC Common Stock 415858109   312,495 6,486 SH   SOLE   6,486 0 0
VNET GROUP INC-ADR ADR 90138A103   309,900 30,000 SH   SOLE   30,000 0 0
ANAPTYSBIO INC Common Stock 032724106   303,352 9,907 SH   SOLE   9,907 0 0
BIOHAVEN LTD Common Stock G1110E107   300,200 20,000 SH   SOLE   20,000 0 0
EDGEWISE THERAPEUTICS INC Common Stock 28036F105   299,519 18,466 SH   SOLE   18,466 0 0
TWIST BIOSCIENCE CORP Common Stock 90184D100   297,721 10,580 SH   SOLE   10,580 0 0
KINIKSA PHARMACEUTICALS INTE Common Stock G52694109   295,885 7,620 SH   SOLE   7,620 0 0
ZOETIS INC Common Stock 98978V103   292,640 2,000 SH   SOLE   2,000 0 0
STRUCTURE THERAPEUTICS INC ADR 86366E106   292,432 10,444 SH   SOLE   10,444 0 0
MANNKIND CORP Common Stock 56400P706   288,809 53,782 SH   SOLE   53,782 0 0
GLOBUS MEDICAL INC - A Common Stock 379577208   286,350 5,000 SH   SOLE   5,000 0 0
PROCEPT BIOROBOTICS CORP Common Stock 74276L105   285,520 8,000 SH   SOLE   8,000 0 0
ZAI LAB LTD-ADR ADR 98887Q104   283,998 8,380 SH   SOLE   8,380 0 0
BIOCRYST PHARMACEUTICALS INC Common Stock 09058V103   279,282 36,796 SH   SOLE   36,796 0 0
VERICEL CORP Common Stock 92346J108   278,352 8,845 SH   SOLE   8,845 0 0
HARMONY BIOSCIENCES HOLDINGS Common Stock 413197104   277,943 10,085 SH   SOLE   10,085 0 0
IRHYTHM TECHNOLOGIES INC Common Stock 450056106   275,184 1,600 SH   SOLE   1,600 0 0
HILTON WORLDWIDE HOLDINGS IN Common Stock 43300A203   264,888 1,021 SH   SOLE   1,021 0 0
ABCELLERA BIOLOGICS INC Common Stock 00288U106   263,476 52,381 SH   SOLE   52,381 0 0
DESIGN THERAPEUTICS INC Common Stock 25056L103   263,414 34,982 SH   SOLE   34,982 0 0
HUMANA INC Common Stock 444859102   260,967 1,000 SH   SOLE   1,000 0 0
AVADEL PHARMACEUTICALS Common Stock G29687103   259,895 17,020 SH   SOLE   17,020 0 0
GSK PLC-SPON ADR ADR 37733W204   259,102 6,000 SH   SOLE   6,000 0 0
JANUX THERAPEUTICS INC Common Stock 47103J105   257,451 10,534 SH   SOLE   10,534 0 0
IMMUNOCORE HOLDINGS PLC-ADR ADR 45258D105   255,073 7,021 SH   SOLE   7,021 0 0
AURINIA PHARMACEUTICALS INC Common Stock 05156V102   254,957 23,073 SH   SOLE   23,073 0 0
NOVOCURE LTD Common Stock G6674U108   253,193 19,597 SH   SOLE   19,597 0 0
AUTOLIV INC Common Stock 052800109   247,000 2,000 SH   SOLE   2,000 0 0
NOVAVAX INC Common Stock 670002401   246,835 28,470 SH   SOLE   28,470 0 0
10X GENOMICS INC-CLASS A Common Stock 88025U109   234,443 20,055 SH   SOLE   20,055 0 0
XPENG INC - ADR ADR 98422D105   234,200 10,000 SH   SOLE   10,000 0 0
ARDELYX INC Common Stock 039697107   232,748 42,241 SH   SOLE   42,241 0 0
SYNDAX PHARMACEUTICALS INC Common Stock 87164F105   232,298 15,099 SH   SOLE   15,099 0 0
XERIS BIOPHARMA HOLDINGS INC Common Stock 98422E103   230,403 28,305 SH   SOLE   28,305 0 0
MONTE ROSA THERAPEUTICS INC Common Stock 61225M102   228,413 30,825 SH   SOLE   30,825 0 0
STOKE THERAPEUTICS INC Common Stock 86150R107   225,718 9,605 SH   SOLE   9,605 0 0
GENMAB A/S -SP ADR ADR 372303206   225,425 7,350 SH   SOLE   7,350 0 0
ZYMEWORKS INC Common Stock 98985Y108   225,046 13,176 SH   SOLE   13,176 0 0
RAPPORT THERAPEUTICS INC Common Stock 75383L102   219,721 7,398 SH   SOLE   7,398 0 0
AMPHASTAR PHARMACEUTICALS IN Common Stock 03209R103   217,198 8,150 SH   SOLE   8,150 0 0
TOURMALINE BIO INC Common Stock 89157D105   215,378 4,503 SH   SOLE   4,503 0 0
GRIFOLS SA-ADR ADR 398438408   212,985 21,384 SH   SOLE   21,384 0 0
CUREVAC NV Common Stock N2451R105   212,722 39,466 SH   SOLE   39,466 0 0
ENLIVEN THERAPEUTICS INC Common Stock 29337E102   212,540 10,383 SH   SOLE   10,383 0 0
AMYLYX PHARMACEUTICALS INC Common Stock 03237H101   212,412 15,630 SH   SOLE   15,630 0 0
DYNAVAX TECHNOLOGIES CORP Common Stock 268158201   204,111 20,555 SH   SOLE   20,555 0 0
PACIRA BIOSCIENCES INC Common Stock 695127100   202,965 7,876 SH   SOLE   7,876 0 0
INNOVIVA INC Common Stock 45781M101   201,608 11,047 SH   SOLE   11,047 0 0
PRAXIS PRECISION MEDICINES I Common Stock 74006W207   195,517 3,689 SH   SOLE   3,689 0 0
TREVI THERAPEUTICS INC Common Stock 89532M101   195,316 21,346 SH   SOLE   21,346 0 0
COLLEGIUM PHARMACEUTICAL INC Common Stock 19459J104   193,215 5,522 SH   SOLE   5,522 0 0
NIO INC - ADR ADR 62914V106   190,500 25,000 SH   SOLE   25,000 0 0
SPYRE THERAPEUTICS INC Common Stock 00773J202   177,438 10,587 SH   SOLE   10,587 0 0
ARS PHARMACEUTICALS INC Common Stock 82835W108   174,096 17,323 SH   SOLE   17,323 0 0
PRECIGEN INC Common Stock 74017N105   171,837 52,230 SH   SOLE   52,230 0 0
PRIME MEDICINE INC Common Stock 74168J101   169,801 30,650 SH   SOLE   30,650 0 0
TANGO THERAPEUTICS INC Common Stock 87583X109   163,817 19,502 SH   SOLE   19,502 0 0
UROGEN PHARMA LTD Common Stock M96088105   161,775 8,109 SH   SOLE   8,109 0 0
SANA BIOTECHNOLOGY INC Common Stock 799566104   160,982 45,347 SH   SOLE   45,347 0 0
RELAY THERAPEUTICS INC Common Stock 75943R102   157,754 30,221 SH   SOLE   30,221 0 0
MIND MEDICINE MINDMED INC Common Stock 60255C885   157,243 13,337 SH   SOLE   13,337 0 0
TAYSHA GENE THERAPIES INC Common Stock 877619106   156,362 47,817 SH   SOLE   47,817 0 0
GERON CORP Common Stock 374163103   153,214 111,835 SH   SOLE   111,835 0 0
ARBUTUS BIOPHARMA CORP Common Stock 03879J100   152,553 33,602 SH   SOLE   33,602 0 0
CORMEDIX INC Common Stock 21900C308   152,179 13,085 SH   SOLE   13,085 0 0
SIONNA THERAPEUTICS INC Common Stock 829401108   147,050 5,000 SH   SOLE   5,000 0 0
XENCOR INC Common Stock 98401F105   146,648 12,502 SH   SOLE   12,502 0 0
PHATHOM PHARMACEUTICALS INC Common Stock 71722W107   146,360 12,435 SH   SOLE   12,435 0 0
PHIBRO ANIMAL HEALTH CORP-A Common Stock 71742Q106   144,442 3,570 SH   SOLE   3,570 0 0
ARCTURUS THERAPEUTICS HOLDIN Common Stock 03969T109   143,017 7,760 SH   SOLE   7,760 0 0
VIR BIOTECHNOLOGY INC Common Stock 92764N102   139,039 24,350 SH   SOLE   24,350 0 0
IOVANCE BIOTHERAPEUTICS INC Common Stock 462260100   137,639 63,428 SH   SOLE   63,428 0 0
KURA ONCOLOGY INC Common Stock 50127T109   134,644 15,214 SH   SOLE   15,214 0 0
FORTREA HOLDINGS INC Common Stock 34965K107   134,013 15,916 SH   SOLE   15,916 0 0
ANAVEX LIFE SCIENCES CORP Common Stock 032797300   133,998 15,056 SH   SOLE   15,056 0 0
ABRDN PHYSICAL SILVER SHARES ETP 003264108   133,440 3,000 SH   SOLE   3,000 0 0
MESOBLAST LTD- SPON ADR ADR 590717401   133,326 8,276 SH   SOLE   8,276 0 0
ARRIVENT BIOPHARMA INC Common Stock 04272N102   131,198 7,111 SH   SOLE   7,111 0 0
TYRA BIOSCIENCES INC Common Stock 90240B106   130,695 9,342 SH   SOLE   9,342 0 0
THERAVANCE BIOPHARMA INC Common Stock G8807B106   128,889 8,828 SH   SOLE   8,828 0 0
DAY ONE BIOPHARMACEUTICALS I Common Stock 23954D109   126,583 17,955 SH   SOLE   17,955 0 0
ORUKA THERAPEUTICS INC Common Stock 687604108   126,245 6,565 SH   SOLE   6,565 0 0
NURIX THERAPEUTICS INC Common Stock 67080M103   123,816 13,400 SH   SOLE   13,400 0 0
AQUESTIVE THERAPEUTICS INC Common Stock 03843E104   118,536 21,205 SH   SOLE   21,205 0 0
OLEMA PHARMACEUTICALS INC Common Stock 68062P106   117,783 12,031 SH   SOLE   12,031 0 0
MEIRAGTX HOLDINGS PLC Common Stock G59665102   116,051 14,101 SH   SOLE   14,101 0 0
CASTLE BIOSCIENCES INC Common Stock 14843C105   115,785 5,085 SH   SOLE   5,085 0 0
TERNS PHARMACEUTICALS INC Common Stock 880881107   115,196 15,339 SH   SOLE   15,339 0 0
SIGA TECHNOLOGIES INC Common Stock 826917106   114,842 12,551 SH   SOLE   12,551 0 0
KEROS THERAPEUTICS INC Common Stock 492327101   112,623 7,119 SH   SOLE   7,119 0 0
TRANSMEDICS GROUP INC Common Stock 89377M109   112,200 1,000 SH   SOLE   1,000 0 0
ARVINAS INC Common Stock 04335A105   109,644 12,869 SH   SOLE   12,869 0 0
ERASCA INC Common Stock 29479A108   108,396 49,723 SH   SOLE   49,723 0 0
SAVARA INC Common Stock 805111101   108,157 30,296 SH   SOLE   30,296 0 0
TECTONIC THERAPEUTIC INC Common Stock 878972108   107,947 6,880 SH   SOLE   6,880 0 0
ANNEXON INC Common Stock 03589W102   107,546 35,261 SH   SOLE   35,261 0 0
KALVISTA PHARMACEUTICALS INC Common Stock 483497103   107,476 8,824 SH   SOLE   8,824 0 0
ENANTA PHARMACEUTICALS INC Common Stock 29251M106   104,702 8,747 SH   SOLE   8,747 0 0
PERSONALIS INC Common Stock 71535D106   101,347 15,544 SH   SOLE   15,544 0 0
TANDEM DIABETES CARE INC Common Stock 875372203   97,120 8,000 SH   SOLE   8,000 0 0
CORVUS PHARMACEUTICALS INC Common Stock 221015100   96,260 13,061 SH   SOLE   13,061 0 0
REZOLUTE INC Common Stock 76200L309   94,000 10,000 SH   SOLE   10,000 0 0
ESPERION THERAPEUTICS INC Common Stock 29664W105   93,654 35,341 SH   SOLE   35,341 0 0
ZEVRA THERAPEUTICS INC Common Stock 488445206   93,578 9,840 SH   SOLE   9,840 0 0
COMPASS PATHWAYS PLC ADR 20451W101   92,115 16,076 SH   SOLE   16,076 0 0
PROTHENA CORP PLC Common Stock G72800108   92,095 9,436 SH   SOLE   9,436 0 0
OMEROS CORP Common Stock 682143102   89,909 21,929 SH   SOLE   21,929 0 0
RIGEL PHARMACEUTICALS INC Common Stock 766559702   89,070 3,144 SH   SOLE   3,144 0 0
MBX BIOSCIENCES INC Common Stock 55287L101   87,500 5,000 SH   SOLE   5,000 0 0
GALAPAGOS NV-SPON ADR ADR 36315X101   86,981 2,511 SH   SOLE   2,511 0 0
LEXICON PHARMACEUTICALS INC Common Stock 528872302   85,992 63,698 SH   SOLE   63,698 0 0
HUTCHMED CHINA-ADR ADR 44842L103   85,633 5,437 SH   SOLE   5,437 0 0
INHIBRX BIOSCIENCES INC Common Stock 45720N103   85,514 2,539 SH   SOLE   2,539 0 0
REGENXBIO INC Common Stock 75901B107   85,441 8,854 SH   SOLE   8,854 0 0
SOLID BIOSCIENCES INC Common Stock 83422E204   84,214 13,649 SH   SOLE   13,649 0 0
CHINA YUCHAI INTL LTD Common Stock G21082105   82,740 2,000 SH   SOLE   2,000 0 0
ABSCI CORP Common Stock 00091E109   79,675 26,209 SH   SOLE   26,209 0 0
PHARVARIS NV Common Stock N69605108   74,850 3,000 SH   SOLE   3,000 0 0
MARAVAI LIFESCIENCES HLDGS-A Common Stock 56600D107   72,783 25,360 SH   SOLE   25,360 0 0
ALPHATEC HOLDINGS INC Common Stock 02081G201   72,700 5,000 SH   SOLE   5,000 0 0
ASTRIA THERAPEUTICS INC Common Stock 04635X102   72,014 9,892 SH   SOLE   9,892 0 0
4D MOLECULAR THERAPEUTICS IN Common Stock 35104E100   71,136 8,186 SH   SOLE   8,186 0 0
EVOLUS INC Common Stock 30052C107   69,615 11,338 SH   SOLE   11,338 0 0
ALUMIS INC Common Stock 022307102   67,758 16,982 SH   SOLE   16,982 0 0
PACIFIC BIOSCIENCES OF CALIF Common Stock 69404D108   67,392 52,650 SH   SOLE   52,650 0 0
AURA BIOSCIENCES INC Common Stock 05153U107   67,294 10,889 SH   SOLE   10,889 0 0
LEXEO THERAPEUTICS INC Common Stock 52886X107   62,854 9,466 SH   SOLE   9,466 0 0
BICYCLE THERAPEUTICS PLC-ADR ADR 088786108   62,725 8,104 SH   SOLE   8,104 0 0
ROCKET PHARMACEUTICALS INC Common Stock 77313F106   61,660 18,914 SH   SOLE   18,914 0 0
CULLINAN THERAPEUTICS INC Common Stock 230031106   61,405 10,355 SH   SOLE   10,355 0 0
ALTIMMUNE INC Common Stock 02155H200   58,322 15,470 SH   SOLE   15,470 0 0
ALPHA TEKNOVA INC Common Stock 02080L102   58,062 9,380 SH   SOLE   9,380 0 0
BRIDGEBIO ONCOLOGY THERAPEUT Common Stock 107924102   57,900 5,000 SH   SOLE   5,000 0 0
AMARIN CORP PLC -ADR ADR 023111404   57,887 3,534 SH   SOLE   3,534 0 0
REPLIMUNE GROUP INC Common Stock 76029N106   57,328 13,682 SH   SOLE   13,682 0 0
AUTOLUS THERAPEUTICS PLC ADR 05280R100   57,306 35,157 SH   SOLE   35,157 0 0
EDITAS MEDICINE INC Common Stock 28106W103   54,694 15,762 SH   SOLE   15,762 0 0
LYELL IMMUNOPHARMA INC Common Stock 55083R203   54,680 3,367 SH   SOLE   3,367 0 0
SCPHARMACEUTICALS INC Common Stock 810648105   52,969 9,342 SH   SOLE   9,342 0 0
ALECTOR INC Common Stock 014442107   52,513 17,741 SH   SOLE   17,741 0 0
MAZE THERAPEUTICS INC Common Stock 578784100   51,860 2,000 SH   SOLE   2,000 0 0
VANDA PHARMACEUTICALS INC Common Stock 921659108   51,681 10,357 SH   SOLE   10,357 0 0
NEUMORA THERAPEUTICS INC Common Stock 640979100   51,664 28,387 SH   SOLE   28,387 0 0
AC IMMUNE SA Common Stock H00263105   50,864 17,600 SH   SOLE   17,600 0 0
LARIMAR THERAPEUTICS INC Common Stock 517125100   48,460 15,003 SH   SOLE   15,003 0 0
FOGHORN THERAPEUTICS INC Common Stock 344174107   48,455 9,909 SH   SOLE   9,909 0 0
HUMACYTE INC Common Stock 44486Q103   48,302 27,760 SH   SOLE   27,760 0 0
ALLOGENE THERAPEUTICS INC Common Stock 019770106   48,226 38,892 SH   SOLE   38,892 0 0
KESTRA MEDICAL TECHNOLOGIES Common Stock G52441105   47,520 2,000 SH   SOLE   2,000 0 0
CARTESIAN THERAPEUTICS INC Common Stock 816212302   46,583 4,558 SH   SOLE   4,558 0 0
KYVERNA THERAPEUTICS INC Common Stock 501976104   45,480 7,580 SH   SOLE   7,580 0 0
VOYAGER THERAPEUTICS INC Common Stock 92915B106   45,406 9,723 SH   SOLE   9,723 0 0
NEUROGENE INC Common Stock 64135M105   43,360 2,502 SH   SOLE   2,502 0 0
SILENCE THERAPEUTICS PLC-ADR ADR 82686Q101   42,724 8,232 SH   SOLE   8,232 0 0
ATEA PHARMACEUTICALS INC Common Stock 04683R106   40,339 13,910 SH   SOLE   13,910 0 0
TVARDI THERAPEUTICS INC Common Stock 140755307   38,970 1,000 SH   SOLE   1,000 0 0
ENTRADA THERAPEUTICS INC Common Stock 29384C108   38,669 6,667 SH   SOLE   6,667 0 0
CODEXIS INC Common Stock 192005106   38,608 15,823 SH   SOLE   15,823 0 0
IRONWOOD PHARMACEUTICALS INC Common Stock 46333X108   37,298 28,472 SH   SOLE   28,472 0 0
IMMUNEERING CORP - CLASS A Common Stock 45254E107   35,000 5,000 SH   SOLE   5,000 0 0
OMNIAB INC Common Stock 68218J103   34,413 21,508 SH   SOLE   21,508 0 0
MAXCYTE INC Common Stock 57777K106   29,525 18,687 SH   SOLE   18,687 0 0
C4 THERAPEUTICS INC Common Stock 12529R107   27,695 12,475 SH   SOLE   12,475 0 0
TEVOGEN BIO HOLDINGS INC Common Stock 88165K101   27,076 34,479 SH   SOLE   34,479 0 0
PEPGEN INC Common Stock 713317105   26,560 5,749 SH   SOLE   5,749 0 0
BURNING ROCK BIOTECH LTD-ADR ADR 12233L206   25,950 3,000 SH   SOLE   3,000 0 0
NKARTA INC Common Stock 65487U108   25,772 12,450 SH   SOLE   12,450 0 0
FATE THERAPEUTICS INC Common Stock 31189P102   25,472 20,216 SH   SOLE   20,216 0 0
PYXIS ONCOLOGY INC Common Stock 747324101   24,134 10,871 SH   SOLE   10,871 0 0
CLIMB BIO INC Common Stock 28658R106   23,875 11,878 SH   SOLE   11,878 0 0
BIOMEA FUSION INC Common Stock 09077A106   21,071 10,431 SH   SOLE   10,431 0 0
AMN HEALTHCARE SERVICES INC Common Stock 001744101   19,360 1,000 SH   SOLE   1,000 0 0
MACROGENICS INC Common Stock 556099109   18,613 11,079 SH   SOLE   11,079 0 0
OCULIS HOLDING AG Common Stock H5870P102   17,580 1,000 SH   SOLE   1,000 0 0
TSCAN THERAPEUTICS INC Common Stock 89854M101   16,739 9,197 SH   SOLE   9,197 0 0
ALIGN TECHNOLOGY INC Common Stock 016255101   16,654 133 SH   SOLE   133 0 0
PLIANT THERAPEUTICS INC Common Stock 729139105   15,925 10,760 SH   SOLE   10,760 0 0
APPLIED THERAPEUTICS INC Common Stock 03828A101   15,269 25,243 SH   SOLE   25,243 0 0
CROSS COUNTRY HEALTHCARE INC Common Stock 227483104   14,200 1,000 SH   SOLE   1,000 0 0
SUTRO BIOPHARMA INC Common Stock 869367102   12,904 14,860 SH   SOLE   14,860 0 0
SURROZEN INC Common Stock 86889P208   12,885 1,000 SH   SOLE   1,000 0 0
ARTIVA BIOTHERAPEUTICS INC Common Stock 04317A107   12,286 4,281 SH   SOLE   4,281 0 0
ACRIVON THERAPEUTICS INC Common Stock 004890109   9,980 5,514 SH   SOLE   5,514 0 0
MERSANA THERAPEUTICS INC Common Stock 59045L205   6,790 875 SH   SOLE   875 0 0
ONKURE THERAPEUTICS INC-A Common Stock 68277Q105   6,190 2,251 SH   SOLE   2,251 0 0
Q32 BIO INC Common Stock 746964105   4,233 2,138 SH   SOLE   2,138 0 0
CHIPOTLE MEXICAN GRILL INC Common Stock 169656105   2,391 61 SH   SOLE   61 0 0
WOLFSPEED INC Common Stock 97785W106   2,374 83 SH   SOLE   83 0 0
HERSHEY CO/THE Common Stock 427866108   1,871 10 SH   SOLE   10 0 0
SPDR S&P 500 ETF TRUST ETP 78462F103   298 0 SH   SOLE   0 0 0