<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <schemaVersion>X0202</schemaVersion>
<headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0001493152-26-021494</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: Newtyn Management, LLC -->
          <cik>0001569241</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>2</amendmentNo>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>06/30/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001906324</issuerCik>
        <issuerName>QuidelOrtho Corporation</issuerName>
        <issuerCusips>
          <issuerCusipNumber>219798105</issuerCusipNumber>
        </issuerCusips>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>9975 Summers Ridge Road</com:street1>
          <com:city>San Diego</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92121</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Newtyn Management, LLC</reportingPersonName>
      <citizenshipOrOrganization>NY</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>6625000.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>6625000.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>6625000.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>9.7</classPercent>
      <typeOfReportingPerson>IA</typeOfReportingPerson>
      <comments>See Item 2 for additional information.</comments>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Newtyn TE Partners, LP</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>4266500.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>4266500.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>4266500.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>6.3</classPercent>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
      <comments>See Item 2 for additional information.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>QuidelOrtho Corporation</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>9975 Summers Ridge Road, San Diego, California 92121</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>This report on Schedule 13G/A (as amended, this "13G") is being filed by (i) Newtyn Management, LLC, a New York limited liability company ("Newtyn Management"), and (ii) Newtyn TE Partners, LP, a Delaware limited partnership ("NTE", and collectively with Newtyn Management, the "Reporting Persons"). Newtyn Management is the investment manager to NTE and Newtyn Partners, LP, a Delaware limited partnership ("NP"). As of June 30, 2026, NTE held 4,266,500 shares of common stock (the "Common Stock") of QuidelOrtho Corporation (the "Issuer") and NP held 2,358,500 shares of Common Stock of the Issuer. Newtyn Management, as the investment manager to NTE and NP, may be deemed to beneficially own these securities. Accordingly, as of June 30, 2026, the Newtyn Management may be deemed to beneficially own the 6,625,000 shares of Common Stock of the Issuer held in the aggregate by NTE and NP. Beneficial ownership percentages are based upon approximately 68,190,989 shares of Common Stock issued and outstanding as of April 28, 2026, based on information reported by the Issuer in its Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on May 6, 2026.</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>The address for the Reporting Persons is 60 East 42nd Street, 12th Floor, New York, NY 10165.</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Newtyn Management is organized under the laws of the State of New York. NTE is organized under the laws of the State of Delaware.</citizenship>
      </item2>
      <item4>
        <amountBeneficiallyOwned>Newtyn Management, LLC - 6,625,000.00

Newtyn TE Partners, LP  - 4,266,500.00</amountBeneficiallyOwned>
        <classPercent>Newtyn Management, LLC - 9.7 %

Newtyn TE Partners, LP - 6.3%</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>Newtyn Management, LLC - 6,625,000.00

Newtyn TE Partners, LP - 4,266,500.00</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>Newtyn Management, LLC  - 0.00

Newtyn TE Partners, LP - 0.00</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>Newtyn Management, LLC  - 6,625,000.00

Newtyn TE Partners, LP - 4,266,500.00</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>Newtyn Management, LLC  - 0.00

Newtyn TE Partners, LP - 0.00</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.</certifications>
      </item10>
    </items>
    <exhibitInfo>Exhibit 1 - Joint Filing Agreement, dated May 6, 2026, by and among Newtyn Management, LLC and Newtyn TE Partners, LP.</exhibitInfo>
    <signatureInformation>
      <reportingPersonName>Newtyn Management, LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Eugene Dozortsev</signature>
        <title>Eugene Dozortsev, Authorized Signatory</title>
        <date>08/14/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Newtyn TE Partners, LP</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Eugene Dozortsev</signature>
        <title>Eugene Dozortsev, Authorized Signatory of Newtyn Management, LLC, the Investment Manager</title>
        <date>08/14/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
