X0306 4 2022-01-15 0 0001453593 Xtant Medical Holdings, Inc. XTNT 0001902610 Neils Scott C 664 CRUISER LANE BELGRADE MT 59714 0 1 0 0 Interim Chief Financial Office Common Stock, $0.000001 par value 2022-01-15 4 A 0 88983 0 A 167108 D Stock Option (right to buy) 0.648 2022-01-15 4 A 0 109164 0 A 2032-01-15 Common Stock 109164 109164 D These shares will vest and be issued with respect to 22,246 shares on each of January 15, 2023, January 15, 2024, and January 15, 2025 and with respect to 22,245 shares on January 15, 2026 pursuant to a restricted stock unit award granted under the Xtant Medical Holdings, Inc. Amended and Restated 2018 Equity Incentive Plan, conditioned upon the Reporting Person remaining an employee of Xtant through the vesting date. Includes 78,125 shares that will be issued over time subject to vesting pursuant to a restricted stock unit granted under the Xtant Medical Holdings, Inc. 2018 Equity Incentive Plan and 88,983 shares that will be issued over time subject to vesting pursuant to a restricted stock unit granted under the Xtant Medical Holdings, Inc. Amended and Restated 2018 Equity Incentive Plan. This option vests with respect to 27,291 shares on January 15, 2023 and with respect to the remaining 75% of such shares over the three-year period thereafter in 12 as nearly equal as possible quarterly installments, conditioned upon the Reporting Person remaining an employee of Xtant through the vesting date. /s/ Amy E. Culbert, attorney-in-fact 2022-01-18