<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
<headerData>
<submissionType>144</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0002061814</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>


</filerInfo>
</headerData>
<formData>
<issuerInfo>
<issuerCik>0001901637</issuerCik>
<issuerName>USCB FINANCIAL HOLDINGS, INC.</issuerName>
<secFileNumber>001-41196</secFileNumber>
<issuerAddress>
<com:street1>2301 NW 87TH AVENUE</com:street1>
<com:city>DORAL</com:city>
<com:stateOrCountry>FL</com:stateOrCountry>
<com:zipCode>33172</com:zipCode>
</issuerAddress>
<issuerContactPhone>(305) 715-5200</issuerContactPhone>
<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Patriot Financial Partners GP II, LLC</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
<relationshipsToIssuer>
<relationshipToIssuer>10% Stockholder</relationshipToIssuer>
</relationshipsToIssuer>
</issuerInfo>
<securitiesInformation>
<securitiesClassTitle>Class A Voting Common Stock</securitiesClassTitle>
<brokerOrMarketmakerDetails>
<name>Keefe, Bruyette &amp; Woods, Inc. </name>
<address>
<com:street1>787 7th Ave, </com:street1>
<com:street2>4th Floor </com:street2>
<com:city>New York</com:city>
<com:stateOrCountry>NY</com:stateOrCountry>
<com:zipCode>10019</com:zipCode>
</address>
</brokerOrMarketmakerDetails>
<noOfUnitsSold>50000</noOfUnitsSold>
<aggregateMarketValue>925000.00</aggregateMarketValue>
<noOfUnitsOutstanding>18547400</noOfUnitsOutstanding>
<approxSaleDate>04/30/2026</approxSaleDate>
<securitiesExchangeName>Nasdaq</securitiesExchangeName>
</securitiesInformation>
<securitiesToBeSold>
<securitiesClassTitle>Class A Voting Common Stock</securitiesClassTitle>
<acquiredDate>12/30/2021</acquiredDate>
<natureOfAcquisitionTransaction>Reorganization</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>4405909</amountOfSecuritiesAcquired>
<paymentDate>12/30/2021</paymentDate>
<natureOfPayment>Stock Exchange</natureOfPayment>
</securitiesToBeSold>
<nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
<remarks>This Form is filed by Patriot Financial Partners GP II, L.P., Patriot Financial Partners II, L.P., Patriot Financial Partners Parallel II, L.P., Patriot Financial Partners GP II, LLC,  W. Kirk Wycoff, James F. Deutsch, Ira M. Lubert and James J. Lynch, which as a group may be deemed to beneficially own greater than 10% of the outstanding shares of Class A Voting Common Stock.
 </remarks>
<noticeSignature>
<noticeDate>04/30/2026</noticeDate>
<signature>/s/ W. Kirk Wycoff</signature>
</noticeSignature>
</formData>
</edgarSubmission>
