144 0001901477 XXXXXXXX LIVE 0001971543 Mural Oncology plc 001-41837 10 Earlsfort Terrace Dublin 2 L2 D02 T380 353-1-905-8020 Goodman Vicki L Officer Ordinary Shares MorganStanley Private Bank

Harborside 2 200 Hudson Street, Suite 501 Jersey City NJ 07311

5069 16870 17062097 11/07/2024 NASDAQ Ordinary Shares 11/06/2024 Restricted Stock Units Issuer N 5069 11/06/2024 Equity Compensation Y Represents shares automatically sold by the Reporting Person to satisfy tax withholding obligations in connection with the vesting of restricted stock units granted to the Reporting Person on December 14, 2023. The automatic sale of the Reporting Person's shares is provided for in a restricted stock unit agreement that includes a "binding contract" consistent with the affirmative defense to liability uner Rule 10b5-1 that was entered on December 21, 2023, and the sale does not represent a discretionary trade by the Reporting Person. 11/08/2024 12/21/2023 /s/ Vicki Goodman