X0206 3 2022-01-03 0 0001761612 BICYCLE THERAPEUTICS plc BCYC 0001901321 Milnes Alistair C/O BICYCLE THERAPEUTICS PLC B900, BABRAHAM RESEARCH CAMPUS CAMBRIDGE X0 CB22 3AT UNITED KINGDOM 0 1 0 0 Chief Operating Officer Employee Stock Option (right to buy) 20.12 2031-01-12 Ordinary Shares 52000 D This option shall vest one-fourth (1/4) of the total number of shares underlying the option on January 4, 2022 and the remaining shares in 36 equal monthly installments thereafter. /s/ Lee Kalowski, Attorney-in-Fact 2022-01-05