<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0708</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001900520</cik>
        <entityName>Lomond Therapeutics Holdings, Inc.</entityName>
        <issuerAddress>
            <street1>8 THE GREEN STE 8490</street1>
            <city>DOVER</city>
            <stateOrCountry>DE</stateOrCountry>
            <stateOrCountryDescription>DELAWARE</stateOrCountryDescription>
            <zipCode>19901</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>212-739-6400</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <previousName>Venetian-1 Acquisition Corp.</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2021</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Iain</firstName>
                <lastName>Dukes</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8 The Green Ste 8490</street1>
                <city>Dover</city>
                <stateOrCountry>DE</stateOrCountry>
                <stateOrCountryDescription>DELAWARE</stateOrCountryDescription>
                <zipCode>19901</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Nikolay</firstName>
                <lastName>Savchuk</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8 The Green Ste 8490</street1>
                <city>Dover</city>
                <stateOrCountry>DE</stateOrCountry>
                <stateOrCountryDescription>DELAWARE</stateOrCountryDescription>
                <zipCode>19901</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Eddie</firstName>
                <middleName>Wang</middleName>
                <lastName>Rodriguez</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8 The Green Ste 8490</street1>
                <city>Dover</city>
                <stateOrCountry>DE</stateOrCountry>
                <stateOrCountryDescription>DELAWARE</stateOrCountryDescription>
                <zipCode>19901</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Carl</firstName>
                <lastName>Gordon</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>8 The Green Ste 8490</street1>
                <city>Dover</city>
                <stateOrCountry>DE</stateOrCountry>
                <stateOrCountryDescription>DELAWARE</stateOrCountryDescription>
                <zipCode>19901</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2024-11-01</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>true</isBusinessCombinationTransaction>
            <clarificationOfResponse>The initial sale of the subject securities occurred concurrently with the closing of a reverse merger with Lomond Operating Co. Such securities were issued to accredited investors.</clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Raymond James &amp; Associates, Inc.</recipientName>
                <recipientCRDNumber>000000705</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>880 Carillon Parkway</street1>
                    <city>St. Petersburg</city>
                    <stateOrCountry>FL</stateOrCountry>
                    <stateOrCountryDescription>FLORIDA</stateOrCountryDescription>
                    <zipCode>33716</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <value>All States</value>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
            <recipient>
                <recipientName>Wedbush &amp; Co., LLC</recipientName>
                <recipientCRDNumber>000328492</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>600 Montgomery Street, 29th Floor</street1>
                    <city>San Francisco</city>
                    <stateOrCountry>CA</stateOrCountry>
                    <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                    <zipCode>94111</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <value>All States</value>
                </statesOfSolicitationList>
                <foreignSolicitation>true</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>43900000</totalOfferingAmount>
            <totalAmountSold>43900000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>$43.9 million shares of common stock, which included (i) 8,241,375 shares of common stock; (ii) 1,078,124 shares of  common stock pursuant to the conversion of SAFEs, and (iii) 2,083,332 shares of common stock pursuant to conversion  of SAFEs.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>27</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>2500000</dollarAmount>
                <isEstimate>true</isEstimate>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>In addition to the sales commissions, warrants to purchase an aggregate of 275,410 shares of our common stock were also issued to the placement agents.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Lomond Therapeutics Holdings, Inc.</issuerName>
                <signatureName>/s/ Iain Dukes</signatureName>
                <nameOfSigner>Iain Dukes</nameOfSigner>
                <signatureTitle>Chief Executive Officer</signatureTitle>
                <signatureDate>2024-11-15</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
