144 0001899390 XXXXXXXX LIVE 0001023459 SIMULATIONS PLUS, INC. 001-32046 800 Park Offices Drive, Suite 401 Research Triangle Park NC 27709 6617237723 JILL FIEDLER-KELLY Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

3150 51408.00 20205482 06/15/2026 NASDAQ Common 06/15/2026 Exercise of Stock Options Issuer N 3150 06/15/2026 Cash N 10b5-1 Sales for JILL FIEDLER-KELLY

800 Park Offices Drive, Suite 401 Research Triangle Park NC 27709

Common 05/11/2026 1000 16530.00 The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 06/15/2026 02/09/2026 /s/ Jill Fiedler-Kelly