CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2025	Sep. 30, 2024
Cash flows used in operating activities:
Net loss	$ (155,063)	$ (153,606)
Adjustments to reconcile net loss to net cash used in operating activities
Stock-based compensation expense	24,753	20,127
Non cash lease expense	7,095	10,147
Depreciation expense	5,445	4,411
Change in fair value of short-term investment — related party	107	544
Amortization of premiums and discount on short-term investments	(1,149)	(2,949)
Changes in operating assets and liabilities:
Collaboration receivable — related party	0	(55,000)
Prepaid expenses and other current assets	1,949	(9,466)
Accounts payable	1,577	(7,717)
Accrued expenses and other current liabilities	(2,760)	1,987
Accrued settlement payment — related party	0	(13,500)
Deferred revenue — related party	(3,608)	71,919
Lease liabilities	(3,654)	(6,007)
Net cash used in operating activities	(125,308)	(139,110)
Cash flows (used in) provided by investing activities:
Maturities of investments	56,681	171,300
Purchases of investments	(189,533)	(146,317)
Purchases of property and equipment	(4,241)	(5,503)
Return (payments) of security deposits	0	724
Net cash (used in) provided by investing activities	(137,093)	20,204
Cash flows provided by financing activities:
Proceeds from follow-on offering, net of issuance costs	138,380	132,055
Proceeds from research and development funding liability	12,000	6,000
Net proceeds from stock option exercises	373	103
Proceeds from ESPP offerings	197	836
Proceeds from issuance of common stock under the BMS Securities Purchase Agreement — related party	0	38,081
Proceeds from issuance of pre-funded warrants, net of issuance costs	0	18,800
Net cash provided by financing activities	150,950	195,875
Net change in cash, cash equivalents, and restricted cash	(111,451)	76,969
Cash, cash equivalents, and restricted cash at beginning of period	196,538	55,070
Cash, cash equivalents, and restricted cash at end of period	85,087	132,039
Reconciliation of cash, cash equivalents and restricted cash:
Cash, cash equivalents, and restricted cash at end of period	85,087	132,039
Less: restricted cash	13,691	14,062
Total cash, and cash equivalents	71,396	117,977
Supplemental cash flow information:
Right-of-use assets obtained in exchange for new operating lease liabilities	83,757	44,935
Decrease in right-of-use assets due to lease termination	3,120	0
Supplemental disclosure of non-cash investing and financing activities:
Purchases of property and equipment included in accounts payable and accrued expenses	$ 0	$ 111