CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
Cash flows used in operating activities:
Net loss	$ (101,088)	$ (81,782)
Adjustments to reconcile net loss to net cash used in operating activities
Stock-based compensation expense	13,300	5,264
Non cash lease expense	7,917	6,304
Depreciation expense	2,853	2,170
Change in fair value of short-term investment — related party	759	1,438
Amortization of premiums and discount on short-term investments	(2,079)	(1,403)
Deferred income taxes	0	(171)
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	(2,519)	(5,299)
Accounts payable	(9,230)	1,104
Accrued expenses and other current liabilities	(3,939)	(3,438)
Accrued settlement payment — related party	(13,500)	0
Lease liabilities	(5,672)	(6,569)
Net cash used in operating activities	(113,198)	(82,382)
Cash flows (used in) provided by investing activities:
Maturities of investments	110,000	65,000
Purchases of investments	(135,912)	(45,659)
Purchases of property and equipment	(4,226)	(3,975)
Payments of security deposits	0	(170)
Net cash (used in) provided by investing activities	(30,138)	15,196
Cash flows provided by financing activities:
Proceeds from follow-on offering, net of issuance costs	132,055	0
Proceeds from issuance of pre-funded warrants, net of issuance costs	18,800	0
Proceeds from research and development funding liability	6,000	0
Proceeds from ESPP offerings	436	0
Net proceeds from stock option exercises	71	143
Net cash provided by financing activities	157,362	143
Net change in cash, cash equivalents, and restricted cash	14,026	(67,043)
Cash, cash equivalents, and restricted cash at beginning of period	55,070	201,116
Cash, cash equivalents, and restricted cash at end of period	69,096	134,073
Reconciliation of cash, cash equivalents and restricted cash:
Cash, cash equivalents, and restricted cash at end of period	69,096	134,073
Less: restricted cash	13,496	13,496
Total cash, and cash equivalents	55,600	120,577
Supplemental cash flow information:
Right-of-use assets obtained in exchange for new operating lease liabilities	44,935	3,265
Supplemental disclosure of non-cash investing and financing activities:
Purchases of property and equipment included in accounts payable and accrued expenses	$ 355	$ 712