3.22.2.2 html 249 285 1 true 58 0 false 9 false false R1.htm 0000001 - Document - Cover Sheet http://www.primemedicine.com/role/Cover Cover Cover 1 false false R2.htm 0000002 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS Sheet http://www.primemedicine.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS CONDENSED CONSOLIDATED BALANCE SHEETS Statements 2 false false R3.htm 0000003 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) Sheet http://www.primemedicine.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSParenthetical CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) Statements 3 false false R4.htm 0000004 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS Sheet http://www.primemedicine.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSS CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS Statements 4 false false R5.htm 0000005 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (Parenthetical) Sheet http://www.primemedicine.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVELOSSParenthetical CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (Parenthetical) Statements 5 false false R6.htm 0000006 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF REDEEMABLE CONVERTIBLE AND CONVERTIBLE??PREFERRED STOCK AND STOCKHOLDERS??? EQUITY (DEFICIT) Sheet http://www.primemedicine.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFREDEEMABLECONVERTIBLEANDCONVERTIBLEPREFERREDSTOCKANDSTOCKHOLDERSEQUITYDEFICIT CONDENSED CONSOLIDATED STATEMENTS OF REDEEMABLE CONVERTIBLE AND CONVERTIBLE??PREFERRED STOCK AND STOCKHOLDERS??? EQUITY (DEFICIT) Statements 6 false false R7.htm 0000007 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF REDEEMABLE CONVERTIBLE AND CONVERTIBLE??PREFERRED STOCK AND STOCKHOLDERS??? EQUITY (DEFICIT) (Parenthetical) Sheet http://www.primemedicine.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFREDEEMABLECONVERTIBLEANDCONVERTIBLEPREFERREDSTOCKANDSTOCKHOLDERSEQUITYDEFICITParenthetical CONDENSED CONSOLIDATED STATEMENTS OF REDEEMABLE CONVERTIBLE AND CONVERTIBLE??PREFERRED STOCK AND STOCKHOLDERS??? EQUITY (DEFICIT) (Parenthetical) Statements 7 false false R8.htm 0000008 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS Sheet http://www.primemedicine.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS Statements 8 false false R9.htm 0000009 - Disclosure - Nature of the Business and Basis of Presentation Sheet http://www.primemedicine.com/role/NatureoftheBusinessandBasisofPresentation Nature of the Business and Basis of Presentation Notes 9 false false R10.htm 0000010 - Disclosure - Summary of Significant Accounting Policies Sheet http://www.primemedicine.com/role/SummaryofSignificantAccountingPolicies Summary of Significant Accounting Policies Notes 10 false false R11.htm 0000011 - Disclosure - Fair Value Measurements Sheet http://www.primemedicine.com/role/FairValueMeasurements Fair Value Measurements Notes 11 false false R12.htm 0000012 - Disclosure - Property and Equipment, Net Sheet http://www.primemedicine.com/role/PropertyandEquipmentNet Property and Equipment, Net Notes 12 false false R13.htm 0000013 - Disclosure - Accrued Expenses and Other Current Liabilities Sheet http://www.primemedicine.com/role/AccruedExpensesandOtherCurrentLiabilities Accrued Expenses and Other Current Liabilities Notes 13 false false R14.htm 0000014 - Disclosure - Convertible Preferred Stock Sheet http://www.primemedicine.com/role/ConvertiblePreferredStock Convertible Preferred Stock Notes 14 false false R15.htm 0000015 - Disclosure - Common Stock Sheet http://www.primemedicine.com/role/CommonStock Common Stock Notes 15 false false R16.htm 0000016 - Disclosure - Stock-Based Compensation Sheet http://www.primemedicine.com/role/StockBasedCompensation Stock-Based Compensation Notes 16 false false R17.htm 0000017 - Disclosure - Leases Sheet http://www.primemedicine.com/role/Leases Leases Notes 17 false false R18.htm 0000018 - Disclosure - License and Collaboration Agreements Sheet http://www.primemedicine.com/role/LicenseandCollaborationAgreements License and Collaboration Agreements Notes 18 false false R19.htm 0000019 - Disclosure - Commitment and Contingencies Sheet http://www.primemedicine.com/role/CommitmentandContingencies Commitment and Contingencies Notes 19 false false R20.htm 0000020 - Disclosure - Net Loss per Share Sheet http://www.primemedicine.com/role/NetLossperShare Net Loss per Share Notes 20 false false R21.htm 0000021 - Disclosure - Related Party Transactions Sheet http://www.primemedicine.com/role/RelatedPartyTransactions Related Party Transactions Notes 21 false false R22.htm 0000022 - Disclosure - Subsequent Events Sheet http://www.primemedicine.com/role/SubsequentEvents Subsequent Events Notes 22 false false R23.htm 0000023 - Disclosure - Summary of Significant Accounting Policies (Policies) Sheet http://www.primemedicine.com/role/SummaryofSignificantAccountingPoliciesPolicies Summary of Significant Accounting Policies (Policies) Policies http://www.primemedicine.com/role/SummaryofSignificantAccountingPolicies 23 false false R24.htm 0000024 - Disclosure - Fair Value Measurements (Tables) Sheet http://www.primemedicine.com/role/FairValueMeasurementsTables Fair Value Measurements (Tables) Tables http://www.primemedicine.com/role/FairValueMeasurements 24 false false R25.htm 0000025 - Disclosure - Property and Equipment, Net (Tables) Sheet http://www.primemedicine.com/role/PropertyandEquipmentNetTables Property and Equipment, Net (Tables) Tables http://www.primemedicine.com/role/PropertyandEquipmentNet 25 false false R26.htm 0000026 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables) Sheet http://www.primemedicine.com/role/AccruedExpensesandOtherCurrentLiabilitiesTables Accrued Expenses and Other Current Liabilities (Tables) Tables http://www.primemedicine.com/role/AccruedExpensesandOtherCurrentLiabilities 26 false false R27.htm 0000027 - Disclosure - Convertible Preferred Stock (Tables) Sheet http://www.primemedicine.com/role/ConvertiblePreferredStockTables Convertible Preferred Stock (Tables) Tables http://www.primemedicine.com/role/ConvertiblePreferredStock 27 false false R28.htm 0000028 - Disclosure - Stock-Based Compensation (Tables) Sheet http://www.primemedicine.com/role/StockBasedCompensationTables Stock-Based Compensation (Tables) Tables http://www.primemedicine.com/role/StockBasedCompensation 28 false false R29.htm 0000029 - Disclosure - Leases (Tables) Sheet http://www.primemedicine.com/role/LeasesTables Leases (Tables) Tables http://www.primemedicine.com/role/Leases 29 false false R30.htm 0000030 - Disclosure - Net Loss per Share (Tables) Sheet http://www.primemedicine.com/role/NetLossperShareTables Net Loss per Share (Tables) Tables http://www.primemedicine.com/role/NetLossperShare 30 false false R31.htm 0000031 - Disclosure - Nature of the Business and Basis of Presentation (Details) Sheet http://www.primemedicine.com/role/NatureoftheBusinessandBasisofPresentationDetails Nature of the Business and Basis of Presentation (Details) Details http://www.primemedicine.com/role/NatureoftheBusinessandBasisofPresentation 31 false false R32.htm 0000032 - Disclosure - Summary of Significant Accounting Policies (Details) Sheet http://www.primemedicine.com/role/SummaryofSignificantAccountingPoliciesDetails Summary of Significant Accounting Policies (Details) Details http://www.primemedicine.com/role/SummaryofSignificantAccountingPoliciesPolicies 32 false false R33.htm 0000033 - Disclosure - Fair Value Measurements - Hierarchy For Assets and Liabilities Measured At Fair Value On A Recurring Basis (Details) Sheet http://www.primemedicine.com/role/FairValueMeasurementsHierarchyForAssetsandLiabilitiesMeasuredAtFairValueOnARecurringBasisDetails Fair Value Measurements - Hierarchy For Assets and Liabilities Measured At Fair Value On A Recurring Basis (Details) Details 33 false false R34.htm 0000034 - Disclosure - Fair Value Measurements - Schedule of Short-Term Investments (Details) Sheet http://www.primemedicine.com/role/FairValueMeasurementsScheduleofShortTermInvestmentsDetails Fair Value Measurements - Schedule of Short-Term Investments (Details) Details 34 false false R35.htm 0000035 - Disclosure - Fair Value Measurements - Contractual Maturities of Short-Term Investments in Available-For-Sale Securities (Details) Sheet http://www.primemedicine.com/role/FairValueMeasurementsContractualMaturitiesofShortTermInvestmentsinAvailableForSaleSecuritiesDetails Fair Value Measurements - Contractual Maturities of Short-Term Investments in Available-For-Sale Securities (Details) Details 35 false false R36.htm 0000036 - Disclosure - Fair Value Measurements - Narrative (Details) Sheet http://www.primemedicine.com/role/FairValueMeasurementsNarrativeDetails Fair Value Measurements - Narrative (Details) Details 36 false false R37.htm 0000037 - Disclosure - Fair Value Measurements - Roll Forward (Details) Sheet http://www.primemedicine.com/role/FairValueMeasurementsRollForwardDetails Fair Value Measurements - Roll Forward (Details) Details 37 false false R38.htm 0000038 - Disclosure - Property and Equipment, Net - Schedule of Property and Equipment, Net (Details) Sheet http://www.primemedicine.com/role/PropertyandEquipmentNetScheduleofPropertyandEquipmentNetDetails Property and Equipment, Net - Schedule of Property and Equipment, Net (Details) Details 38 false false R39.htm 0000039 - Disclosure - Property and Equipment, Net - Narrative (Details) Sheet http://www.primemedicine.com/role/PropertyandEquipmentNetNarrativeDetails Property and Equipment, Net - Narrative (Details) Details 39 false false R40.htm 0000040 - Disclosure - Accrued Expenses and Other Current Liabilities (Details) Sheet http://www.primemedicine.com/role/AccruedExpensesandOtherCurrentLiabilitiesDetails Accrued Expenses and Other Current Liabilities (Details) Details http://www.primemedicine.com/role/AccruedExpensesandOtherCurrentLiabilitiesTables 40 false false R41.htm 0000041 - Disclosure - Convertible Preferred Stock - Narrative (Details) Sheet http://www.primemedicine.com/role/ConvertiblePreferredStockNarrativeDetails Convertible Preferred Stock - Narrative (Details) Details 41 false false R42.htm 0000042 - Disclosure - Convertible Preferred Stock - Preferred Stock at Balance Sheet Date (Details) Sheet http://www.primemedicine.com/role/ConvertiblePreferredStockPreferredStockatBalanceSheetDateDetails Convertible Preferred Stock - Preferred Stock at Balance Sheet Date (Details) Details 42 false false R43.htm 0000043 - Disclosure - Common Stock (Details) Sheet http://www.primemedicine.com/role/CommonStockDetails Common Stock (Details) Details http://www.primemedicine.com/role/CommonStock 43 false false R44.htm 0000044 - Disclosure - Stock-Based Compensation - Narrative (Details) Sheet http://www.primemedicine.com/role/StockBasedCompensationNarrativeDetails Stock-Based Compensation - Narrative (Details) Details 44 false false R45.htm 0000045 - Disclosure - Stock-Based Compensation - Stock Option Activity (Details) Sheet http://www.primemedicine.com/role/StockBasedCompensationStockOptionActivityDetails Stock-Based Compensation - Stock Option Activity (Details) Details 45 false false R46.htm 0000046 - Disclosure - Stock-Based Compensation - Restricted Stock Activity (Details) Sheet http://www.primemedicine.com/role/StockBasedCompensationRestrictedStockActivityDetails Stock-Based Compensation - Restricted Stock Activity (Details) Details 46 false false R47.htm 0000047 - Disclosure - Stock-Based Compensation - Stock-Based Compensation Classification (Details) Sheet http://www.primemedicine.com/role/StockBasedCompensationStockBasedCompensationClassificationDetails Stock-Based Compensation - Stock-Based Compensation Classification (Details) Details 47 false false R48.htm 0000048 - Disclosure - Leases - Narrative (Details) Sheet http://www.primemedicine.com/role/LeasesNarrativeDetails Leases - Narrative (Details) Details 48 false false R49.htm 0000049 - Disclosure - Leases - Schedule of Maturity (Details) Sheet http://www.primemedicine.com/role/LeasesScheduleofMaturityDetails Leases - Schedule of Maturity (Details) Details 49 false false R50.htm 0000050 - Disclosure - License and Collaboration Agreements (Details) Sheet http://www.primemedicine.com/role/LicenseandCollaborationAgreementsDetails License and Collaboration Agreements (Details) Details http://www.primemedicine.com/role/LicenseandCollaborationAgreements 50 false false R51.htm 0000051 - Disclosure - Commitment and Contingencies (Details) Sheet http://www.primemedicine.com/role/CommitmentandContingenciesDetails Commitment and Contingencies (Details) Details http://www.primemedicine.com/role/CommitmentandContingencies 51 false false R52.htm 0000052 - Disclosure - Net Loss per Share - Schedule of Basic and Diluted Earnings per Share (Details) Sheet http://www.primemedicine.com/role/NetLossperShareScheduleofBasicandDilutedEarningsperShareDetails Net Loss per Share - Schedule of Basic and Diluted Earnings per Share (Details) Details 52 false false R53.htm 0000053 - Disclosure - Net Loss per Share - Schedule of Antidilutive Securities (Details) Sheet http://www.primemedicine.com/role/NetLossperShareScheduleofAntidilutiveSecuritiesDetails Net Loss per Share - Schedule of Antidilutive Securities (Details) Details 53 false false R54.htm 0000054 - Disclosure - Related Party Transactions (Details) Sheet http://www.primemedicine.com/role/RelatedPartyTransactionsDetails Related Party Transactions (Details) Details http://www.primemedicine.com/role/RelatedPartyTransactions 54 false false R55.htm 0000055 - Disclosure - Subsequent Events (Details) Sheet http://www.primemedicine.com/role/SubsequentEventsDetails Subsequent Events (Details) Details http://www.primemedicine.com/role/SubsequentEvents 55 false false All Reports Book All Reports [ix-0514-Hidden-Fact-Eligible-For-Transform] WARN: 5 fact(s) appearing in ix:hidden were eligible for transformation: us-gaap:PreferredStockConvertibleConversionRatio, us-gaap:StockholdersEquityNoteStockSplitConversionRatio1 - prme-20220930.htm 4 prme-20220930.htm ex311.htm ex312.htm ex321.htm ex322.htm prme-20220930.xsd prme-20220930_cal.xml prme-20220930_def.xml prme-20220930_lab.xml prme-20220930_pre.xml http://fasb.org/us-gaap/2022 http://xbrl.sec.gov/dei/2022 true true