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    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001893645</cik>
        <entityName>Polyrizon Ltd.</entityName>
        <issuerAddress>
            <street1>8 HAPNINA STREET</street1>
            <city>RAANANA</city>
            <stateOrCountry>L3</stateOrCountry>
            <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
            <zipCode>4321545</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>+972-9-3740120</issuerPhoneNumber>
        <jurisdictionOfInc>ISRAEL</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Tomer</firstName>
                <lastName>Izraeli</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>POLYRIZON LTD.</street1>
                <street2>8 HaPnina Street</street2>
                <city>Raanana</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>4321545</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Executive Officer and Director</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Nir</firstName>
                <middleName>Ben</middleName>
                <lastName>Yosef</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>POLYRIZON LTD.</street1>
                <street2>8 HaPnina Street</street2>
                <city>Raanana</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>4321545</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Financial Officer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Eyal</firstName>
                <lastName>Ron</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>POLYRIZON LTD.</street1>
                <street2>8 HaPnina Street</street2>
                <city>Raanana</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>4321545</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Science Officer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Tidhar</firstName>
                <lastName>Turgeman</lastName>
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                <street1>POLYRIZON LTD.</street1>
                <street2>8 HaPnina Street</street2>
                <city>Raanana</city>
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                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>4321545</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Technology Officer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Asaf</firstName>
                <lastName>Itzhaik</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>POLYRIZON LTD.</street1>
                <street2>8 HaPnina Street</street2>
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                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
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            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Oz</firstName>
                <lastName>Adler</lastName>
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            <relatedPersonAddress>
                <street1>POLYRIZON LTD.</street1>
                <street2>8 HaPnina Street</street2>
                <city>Raanana</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>4321545</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Liat</firstName>
                <lastName>Sidi</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>POLYRIZON LTD.</street1>
                <street2>8 HaPnina Street</street2>
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                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
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            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Yehonatan</firstName>
                <middleName>Zalman</middleName>
                <lastName>Vinokur</lastName>
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            <relatedPersonAddress>
                <street1>POLYRIZON LTD.</street1>
                <street2>8 HaPnina Street</street2>
                <city>Raanana</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>4321545</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Liron</firstName>
                <lastName>Carmel</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>POLYRIZON LTD.</street1>
                <street2>8 HaPnina Street</street2>
                <city>Raanana</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
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            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2026-04-07</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Aegis Capital Corp.</recipientName>
                <recipientCRDNumber>000015007</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>1345 Avenue of the Americas</street1>
                    <street2>27th Floor</street2>
                    <city>New York</city>
                    <stateOrCountry>X1</stateOrCountry>
                    <stateOrCountryDescription>UNITED STATES</stateOrCountryDescription>
                    <zipCode>10105</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <value>All States</value>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>3499992</totalOfferingAmount>
            <totalAmountSold>3499992</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>The warrants and shares underlying the warrants, were issued in connection with an offering of (i) 87,777 ordinary shares and warrants to purchase 190,000 ordinary shares in a registered direct offering, and (ii) unregistered warrants to purchase 499,999</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>280000</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>Aegis Capital Corp. is entitled to a cash placement fee equal to 8.0% of the gross proceeds received in the offering and $75,000 for reasonable legal fees and disbursements for its counsel.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>The Company intends to use the net proceeds from the offering, together with its existing cash, for general corporate purposes and working capital.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Polyrizon Ltd.</issuerName>
                <signatureName>/s/ Tomer Izraeli</signatureName>
                <nameOfSigner>Tomer Izraeli</nameOfSigner>
                <signatureTitle>Chief Executive Officer</signatureTitle>
                <signatureDate>2026-04-23</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
