The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Alphabet Inc-Cl C Common 02079K107   18,725 112,000 SH   DFND 1 112,000 0 0
AbbVie Inc. Common 00287Y109   9,947 5,037 SH   DFND 1 5,037 0 0
Adobe Common 00724f101   181 35 SH   DFND 1 35 0 0
AllianceBernstein Holding L.P. Common 01881G106   16,747 48,000 SH   DFND 1 48,000 0 0
Alphabet Inc CL A Common 02079k305   497 300 SH   DFND 1 300 0 0
Alphabet Inc-Cl C Common 02079K107   368 220 SH   DFND 1 220 0 0
Amazon.com Inc. Common 023135106   559 300 SH   DFND 1 300 0 0
Apollo Global Management, Inc. Common 03769M106   28,105 225,000 SH   DFND 1 225,000 0 0
Apple Inc. Common 037833100   5,809 2,494 SH   DFND 1 2,494 0 0
Arc Resources Ltd. Common 03940R107   187 1,110 SH   DFND 1 1,110 0 0
Ardelyx, Inc. Common 039697107   4,705 682,867 SH   DFND 1 682,867 0 0
aTyr Pharma, Inc. Common 002120202   189 107,174 SH   DFND 1 107,174 0 0
Avadel Pharmaceuticals plc Common 05337M104   4,354 332,000 SH   DFND 1 332,000 0 0
Blackstone Group LP Common 09260d107   32 210 SH   DFND 1 210 0 0
BioCryst Pharmaceuticals Inc. Common 09058V103   2,903 382,000 SH   DFND 1 382,000 0 0
BioMarin Pharmaceuticals Inc. Common 09061G101   2,390 34,000 SH   DFND 1 34,000 0 0
Broadcom, Inc. Common 11135F101   122 710 SH   DFND 1 710 0 0
Calumet Specialty Products Partners, LP Common 131428104   77,072 4,325,000 SH   DFND 1 4,325,000 0 0
Canadian Natural Resources Limited Common 136385101   558 16,800 SH   DFND 1 16,800 0 0
Catalyst Pharmaceuticals, Inc. Common 14888U101   4,215 212,000 SH   DFND 1 212,000 0 0
Chipotle Mexican Grill, Inc. Common 169656105   29 500 SH   DFND 1 500 0 0
Coca-Cola Co. Common 191216100   144 2,000 SH   DFND 1 2,000 0 0
Corteva, Inc. Common 22052L104   680 11,563 SH   DFND 1 11,563 0 0
CSX Corporation Common 126408103   2,417 70,000 SH   DFND 1 70,000 0 0
Danaher Corporation Common 235851102   50 180 SH   DFND 1 180 0 0
Digimarc Corporation Common 25381B101   2,246 83,557 SH   DFND 1 83,557 0 0
DocGo, Inc. Common 256086109   10,195 3,070,850 SH   DFND 1 3,070,850 0 0
Dow Inc. Common 260557103   66 1,206 SH   DFND 1 1,206 0 0
DuPont de Nemours, Inc. Common 26614N102   885 9,930 SH   DFND 1 9,930 0 0
Eastern Bankshares Inc Common 27627N105   82 5,000 SH   DFND 1 5,000 0 0
Editas Medicine, Inc. Common 28106W103   463 135,853 SH   DFND 1 135,853 0 0
Eli Lilly & Co. Common 532457108   266 300 SH   DFND 1 300 0 0
Enstar Group Limited Common G3075P101   2,412 7,500 SH   DFND 1 7,500 0 0
Evolus, Inc. Common 30052C107   933 57,570 SH   DFND 1 57,570 0 0
FS Bancorp, Inc. Common 30263Y104   65 1,460 SH   DFND 1 1,460 0 0
FS KKR Capital Corp. Common 302635206   57 2,875 SH   DFND 1 2,875 0 0
GE HealthCare Technologies Inc Common 36266G107   5 50 SH   DFND 1 50 0 0
General Electric Company Common 369604301   28 150 SH   DFND 1 150 0 0
GSK plc Common 37733W204   2,657 65,000 SH   DFND 1 65,000 0 0
Home Depot Inc. Common 437076102   32 80 SH   DFND 1 80 0 0
Immunovant Inc. Common 45258J102   2,623 92,000 SH   DFND 1 92,000 0 0
Inozyme Pharma, Inc. Common 45790W108   2,953 564,549 SH   DFND 1 564,549 0 0
International Business Machines Common 459200101   474 2,142 SH   DFND 1 2,142 0 0
International Game Technology PLC Common 459902102   53 2,500 SH   DFND 1 2,500 0 0
Ironwood Pharmaceuticalss, Inc. Common 46333X108   853 207,033 SH   DFND 1 207,033 0 0
iShares Russell Mid-Cap Growth Common 464287481   82 695 SH   DFND 1 695 0 0
Janus Henderson AAA CLO ETF Common 47103U845   2,717 53,397 SH   DFND 1 53,397 0 0
Janus Henderson AAA CLO ETF Common 47103U845   1,599 31,432 SH   DFND 1 31,432 0 0
Johnson & Johnson Common 478160104   149 922 SH   DFND 1 922 0 0
JPMorgan Chase & Co. Common 46625H100   4,425 20,985 SH   DFND 1 20,985 0 0
Kenvue, Inc. Common 49177J102   52 2,235 SH   DFND 1 2,235 0 0
Kimberly-Clark Corporation Common 494368103   854 6,000 SH   DFND 1 6,000 0 0
Kyndryl Holdings Inc. Common 50155Q100   10 428 SH   DFND 1 428 0 0
Kura Oncology Inc. Common 50127T109   371 19,000 SH   DFND 1 19,000 0 0
Leap Therapeutics, Inc. Common 52187K200   168 65,328 SH   DFND 1 65,328 0 0
Legacy Housing Corporation Common 52472M101   178 6,500 SH   DFND 1 6,500 0 0
Lexicon Pharmaceuticals Inc. Common 528872302   785 500,000 SH   DFND 1 500,000 0 0
Linde PLC Common G5494J103   33 70 SH   DFND 1 70 0 0
MeiraGTx Holdings PLC Common G59665102   20 4,703 SH   DFND 1 4,703 0 0
Medical Facilities Corp Common 58457V503   5,328 534,207 SH   DFND 1 534,207 0 0
Mereo BioPharm Group PLC Common 589492107   1,360 331,000 SH   DFND 1 331,000 0 0
Microsoft Corporation Common 594918104   688 1,600 SH   DFND 1 1,600 0 0
Mondelez International, Inc. Common 609207105   663 9,000 SH   DFND 1 9,000 0 0
Nvidia Corp Common 67066G104   155 1,280 SH   DFND 1 1,280 0 0
Occidental Petroleum Corporation Common 674599105   54 1,055 SH   DFND 1 1,055 0 0
Occidential Pertro Wts exp. 8/3/27 Common 674599105   4 194 SH   DFND 1 194 0 0
OmniAB, Inc. Common 68218J103   4,858 1,148,505 SH   DFND 1 1,148,505 0 0
Pfizer Inc. Common 717081103   4,052 140,000 SH   DFND 1 140,000 0 0
Pfizer Inc. Common 717081103   2,447 84,537 SH   DFND 1 84,537 0 0
Protagonist Therapeutics, Inc Common 74366E102   2,357 52,368 SH   DFND 1 52,368 0 0
Quanta Services, Inc. Common 74762E102   52 176 SH   DFND 1 176 0 0
Revance Therapeutics Inc. Common 761330109   163 31,355 SH   DFND 1 31,355 0 0
Roivant Science Ltd. Common G76279101   711 61,583 SH   DFND 1 61,583 0 0
Ryman Hospitality Properties, Inc. Common 78377T107   1,287 12,000 SH   DFND 1 12,000 0 0
Salesforce, Inc. Common 79466L302   21 77 SH   DFND 1 77 0 0
South State Corporation Common 840441109   52 534 SH   DFND 1 534 0 0
SPDR S&P Biotech ETF Common 78464A870   988 10,000 SH   DFND 1 10,000 0 0
Starwood Property Trust, Inc. Common 85571B105   8 400 SH   DFND 1 400 0 0
Syndax Pharmaceutical, Inc. Common 87164F105   2,351 122,144 SH   DFND 1 122,144 0 0
The Invesco AAA Floating Rate Note ETF Common 46090A721   3,035 118,385 SH   DFND 1 118,385 0 0
The Invesco AAA Floating Rate Note ETF Common 46090A721   1,808 70,502 SH   DFND 1 70,502 0 0
The Panagram AAA CLO ETF Common 81752T486   353 13,806 SH   DFND 1 13,806 0 0
The Panagram AAA CLO ETF Common 81752T486   147 5,766 SH   DFND 1 5,766 0 0
The Panagram BBB-B CLO ETF Common 81752T528   6,830 254,079 SH   DFND 1 254,079 0 0
The Panagram BBB-B CLO ETF Common 81752T528   7,763 288,789 SH   DFND 1 288,789 0 0
Thermo Fisher Scientific, Inc. Common 883556102   28 45 SH   DFND 1 45 0 0
TotalEnergies SE - ADR Common 89151E109   78 1,200 SH   DFND 1 1,200 0 0
Travere Therapeutics, Inc. Common 89422G107   3,613 258,231 SH   DFND 1 258,231 0 0
United Healthcare Corp. Common 91324p102   33 57 SH   DFND 1 57 0 0
United Rental, Inc. Common 911363109   63 78 SH   DFND 1 78 0 0
Verona Pharma PLC. Common 925050106   5,179 180,000 SH   DFND 1 180,000 0 0
Vertex Pharmaceuticals, Inc. Common 92532F100   930 2,000 SH   DFND 1 2,000 0 0
Viking Therapeutics, Inc. Common 92686J106   2,471 39,036 SH   DFND 1 39,036 0 0
Wabtec Corporation Common 929740108   1 6 SH   DFND 1 6 0 0
X4 Pharmaceutials, Inc. Common 98420X103   103 154,071 SH   DFND 1 154,071 0 0
Xenon Pharmaceuticals Inc. Common 98420N105   821 20,866 SH   DFND 1 20,866 0 0
Xeris Biopharma Holdings, Inc. Common 98422E103   2,850 1,000,000 SH   DFND 1 1,000,000 0 0
XOMA Corporation Common 98419J206   522 19,722 SH   DFND 1 19,722 0 0
Zimvie Inc. Common 98888T107   567 35,750 SH   DFND 1 35,750 0 0