Summary of Significant Accounting Policies - Segments (Details) $ in Thousands	3 Months Ended
	Mar. 31, 2026 USD ($) segment	Mar. 31, 2025 USD ($)
Summary of Significant Accounting Policies
Number of reportable segments | segment	1
Number of operating segments | segment	1
Operating expenses:
General and administrative	$ 22,872	$ 13,444
Total operating expenses	89,379	56,311
Loss from operations	(89,379)	(56,311)
Interest and other income, net	13,601	9,576
Loss before provision for income taxes	(75,778)	(46,735)
Provision for income taxes	190	98
Net loss attributable to ordinary shareholders	(75,968)	(46,833)
Single Reporting Segment
Operating expenses:
Discovery research and development	18,517	21,787
Manufacturing	4,270
Clinical research and development	35,196	17,157
Other research and development expenses	8,524	3,923
General and administrative	22,872	13,444
Total operating expenses	89,379	56,311
Loss from operations	(89,379)	(56,311)
Interest and other income, net	13,601	9,576
Loss before provision for income taxes	(75,778)	(46,735)
Provision for income taxes	190	98
Net loss attributable to ordinary shareholders	$ (75,968)	$ (46,833)