X0609 4 2026-06-09 0001817241 Artiva Biotherapeutics, Inc. ARTV 0001346824 RA CAPITAL MANAGEMENT, L.P. false 200 BERKELEY STREET, 18TH FLOOR BOSTON MA 02116 true false true false 0001315082 RA Capital Healthcare Fund LP false 200 BERKELEY STREET, 18TH FLOOR BOSTON MA 02116 1 0 1 0 0001780117 RA Capital Nexus Fund, L.P. false 200 BERKELEY STREET, 18TH FLOOR BOSTON MA 02116 1 0 0 0 0001883840 RA Capital Nexus Fund III, L.P. false 200 BERKELEY STREET, 18TH FLOOR BOSTON MA 02116 1 0 0 0 0001384859 Kolchinsky Peter false C/O RA CAPITAL MANAGEMENT, L.P. 200 BERKELEY STREET, 18TH FLOOR BOSTON MA 02116 1 0 1 0 0001619841 Shah Rajeev M. false C/O RA CAPITAL MANAGEMENT, L.P. 200 BERKELEY STREET, 18TH FLOOR BOSTON MA 02116 1 0 1 0 0 Common Stock 2026-06-09 4 P 0 479039 6.91 A 15683034 I See footnotes Common Stock 2026-06-10 4 P 0 103 7 A 15683137 I See footnotes Common Stock 2026-06-11 4 P 0 548580 7.91 A 16231717 I See footnotes Common Stock 264571 I See footnotes Common Stock 826832 I See footnotes Common Stock 68320 I See footnotes The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $6.77 to $7.00 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund"), RA Capital Nexus Fund, L.P. (the "Nexus Fund"), RA Capital Nexus III Fund, L.P. (the "Nexus Fund III"), and a separately managed account (the "Account"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, the Fund, the Nexus Fund, the Nexus Fund III, Dr. Kolchinsky and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein. Held directly by the Fund. The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $7.605 to $8.00 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. Held directly by the Nexus Fund. Held directly by Nexus Fund III. Held directly by the Account. Laura Stoppel, a Principal of the Adviser, serves on the Issuer's board of directors /s/ Peter Kolchinsky, Manager of RA Capital Management, L.P. 2026-06-11 /s/ Peter Kolchinsky, Manager of RA Capital Healthcare Fund GP, LLC, the General Partner of RA Capital Healthcare Fund, L.P. 2026-06-11 /s/ Peter Kolchinsky, Manager of RA Capital Nexus Fund GP, LLC, the General Partner of RA Capital Nexus Fund, L.P. 2026-06-11 /s/ Peter Kolchinsky, Manager of RA Capital Nexus Fund III GP, LLC, the General Partner of RA Capital Nexus Fund III, L.P. 2026-06-11 /s/ Peter Kolchinsky, individually 2026-06-11 /s/ Rajeev Shah, individually 2026-06-11