<?xml version="1.0" encoding="UTF-8"?><own:edgarSubmission xmlns:com="http://www.sec.gov/edgar/common" xmlns:own="http://www.sec.gov/edgar/ownership">
  <!-- Generated by Workiva -->
  <own:headerData>
    <own:submissionType>144</own:submissionType>
    <own:filerInfo>
      <own:filer>
        <own:filerCredentials>
          <own:cik>0001883764</own:cik>
          <own:ccc>XXXXXXXX</own:ccc>
        </own:filerCredentials>
      </own:filer>
      <own:liveTestFlag>LIVE</own:liveTestFlag>



    </own:filerInfo>
  </own:headerData>
  <own:formData>
    <own:issuerInfo>
      <own:issuerCik>0000882796</own:issuerCik>
      <own:issuerName>BIOCRYST PHARMACEUTICALS, INC.</own:issuerName>
      <own:secFileNumber>000-23186</own:secFileNumber>
      <own:issuerAddress>
        <com:street1>4505 Emperor BLVD</com:street1>
        <com:street2>Suite 200</com:street2>
        <com:city>Durham</com:city>
        <com:stateOrCountry>NC</com:stateOrCountry>
        <com:zipCode>27703</com:zipCode>
      </own:issuerAddress>
      <own:issuerContactPhone>9198591302</own:issuerContactPhone>
      <own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Amy McKee</own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <own:relationshipsToIssuer>
        <own:relationshipToIssuer>Director</own:relationshipToIssuer>
      </own:relationshipsToIssuer>
    </own:issuerInfo>
    <own:securitiesInformation>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:brokerOrMarketmakerDetails>
        <own:name>Merrill Lynch</own:name>
        <own:address>
          <com:street1>1800 K ST NW</com:street1>
          <com:street2>Suite 800</com:street2>
          <com:city>Washington</com:city>
          <com:stateOrCountry>DC</com:stateOrCountry>
          <com:zipCode>20006</com:zipCode>
        </own:address>
      </own:brokerOrMarketmakerDetails>
      <own:noOfUnitsSold>11180</own:noOfUnitsSold>
      <own:aggregateMarketValue>99906</own:aggregateMarketValue>
      <own:noOfUnitsOutstanding>254162660</own:noOfUnitsOutstanding>
      <own:approxSaleDate>05/18/2026</own:approxSaleDate>
      <own:securitiesExchangeName>NASDAQ</own:securitiesExchangeName>
    </own:securitiesInformation>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:acquiredDate>06/07/2023</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Stock Plan Activity</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Issuer</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>4360</own:amountOfSecuritiesAcquired>
      <own:paymentDate>06/07/2023</own:paymentDate>
      <own:natureOfPayment>n/a</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:acquiredDate>06/12/2025</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Stock Plan Activity</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Issuer</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>6820</own:amountOfSecuritiesAcquired>
      <own:paymentDate>06/12/2025</own:paymentDate>
      <own:natureOfPayment>n/a</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</own:nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <own:noticeSignature>
      <own:noticeDate>05/18/2026</own:noticeDate>
      <own:signature>Amy McKee</own:signature>
    </own:noticeSignature>
  </own:formData>
</own:edgarSubmission>
