144 0001881007 XXXXXXXX LIVE 0001658247 Crinetics Pharmaceuticals, Inc. 001-38583 6055 LUSK BOULEVARD SAN DIEGO CA 92121 858-450-6464 Knight Jeff E. Officer COMMON Morgan Stanley Smith Barney LLC Executive Services

200 W Civic Center Dr - 4th Floor SANDY UT 84070

31271 1376102.19 69600000 03/22/2024 NASDAQ COMMON 03/22/2024 STOCK OPTION EXERCISE ISSUER N 30000 03/22/2024 COMPENSATION COMMON 03/15/2024 RESTRICTED STOCK ISSUER N 621 03/15/2024 COMPENSATION COMMON 03/15/2023 RESTRICTED STOCK ISSUER N 650 03/15/2023 COMPENSATION N JEFF KNIGHT

6055 LUSK BOULEVARD SAN DIEGO CA 92121

ESPP 03/21/2024 2359 107082.56 JEFF KNIGHT

6055 LUSK BOULEVARD SAN DIEGO CA 92121

RESTRICTED STOCK 03/18/2024 4283 163359.81 03/22/2024 /s/ Jeff Knight