<?xml version="1.0" encoding="UTF-8"?><own:edgarSubmission xmlns:own="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <own:headerData>
    <own:submissionType>144</own:submissionType>
    <own:filerInfo>
      <own:filer>
        <own:filerCredentials>
          <own:cik>0001880946</own:cik>
          <own:ccc>XXXXXXXX</own:ccc>
        </own:filerCredentials>
      </own:filer>
      <own:liveTestFlag>LIVE</own:liveTestFlag>



    </own:filerInfo>
  </own:headerData>
  <own:formData>
    <own:issuerInfo>
      <own:issuerCik>0001863127</own:issuerCik>
      <own:issuerName>Tyra Biosciences, Inc.</own:issuerName>
      <own:issuerAddress>
        <com:street1>2656 State St</com:street1>
        <com:city>Carlsbad</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>92008</com:zipCode>
      </own:issuerAddress>
      <own:issuerContactPhone>6197284760</own:issuerContactPhone>
      <own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Daniel Bensen</own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <own:relationshipsToIssuer>
        <own:relationshipToIssuer>Officer</own:relationshipToIssuer>
      </own:relationshipsToIssuer>
    </own:issuerInfo>
    <own:securitiesInformation>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:brokerOrMarketmakerDetails>
        <own:name>Merrill Lynch</own:name>
        <own:address>
          <com:street1>2049 Century Park E, Ste 1200</com:street1>
          <com:city>Los Angeles</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>90067</com:zipCode>
        </own:address>
      </own:brokerOrMarketmakerDetails>
      <own:noOfUnitsSold>8000</own:noOfUnitsSold>
      <own:aggregateMarketValue>285000</own:aggregateMarketValue>
      <own:noOfUnitsOutstanding>53372098</own:noOfUnitsOutstanding>
      <own:approxSaleDate>04/13/2026</own:approxSaleDate>
      <own:securitiesExchangeName>Nasdaq</own:securitiesExchangeName>
    </own:securitiesInformation>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:acquiredDate>08/28/2018</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Founders shares</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Issuer</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>8000</own:amountOfSecuritiesAcquired>
      <own:paymentDate>08/28/2018</own:paymentDate>
      <own:natureOfPayment>n/a</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:nothingToReportFlagOnSecuritiesSoldInPast3Months>N</own:nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>Daniel Bensen</own:name>
        <own:address>
          <com:street1>2656 State St</com:street1>
          <com:city>Carlsbad</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92008</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:saleDate>02/12/2026</own:saleDate>
      <own:amountOfSecuritiesSold>8000</own:amountOfSecuritiesSold>
      <own:grossProceeds>262000</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:securitiesSoldInPast3Months>
      <own:sellerDetails>
        <own:name>Daniel Bensen</own:name>
        <own:address>
          <com:street1>2656 State St</com:street1>
          <com:city>Carlsbad</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92008</com:zipCode>
        </own:address>
      </own:sellerDetails>
      <own:securitiesClassTitle>Common</own:securitiesClassTitle>
      <own:saleDate>03/12/2026</own:saleDate>
      <own:amountOfSecuritiesSold>8000</own:amountOfSecuritiesSold>
      <own:grossProceeds>181000</own:grossProceeds>
    </own:securitiesSoldInPast3Months>
    <own:noticeSignature>
      <own:noticeDate>04/13/2026</own:noticeDate>
      <own:planAdoptionDates>
        <own:planAdoptionDate>11/05/2024</own:planAdoptionDate>
      </own:planAdoptionDates>
      <own:signature>Daniel Bensen</own:signature>
    </own:noticeSignature>
  </own:formData>
</own:edgarSubmission>
