<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0609</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2026-06-12-05:00</periodOfReport>

    <notSubjectToSection16>true</notSubjectToSection16>

    <issuer>
        <issuerCik>0002032950</issuerCik>
        <issuerName>Horizon Space Acquisition II Corp.</issuerName>
        <issuerTradingSymbol>HSPT</issuerTradingSymbol>
        <issuerForeignTradingSymbol></issuerForeignTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001879076</rptOwnerCik>
            <rptOwnerName>Xu Qian</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerNonUSAddressFlag>false</rptOwnerNonUSAddressFlag>
            <rptOwnerStreet1>C/O HORIZON SPACE ACQUISITION II CORP.</rptOwnerStreet1>
            <rptOwnerStreet2>1412 BROADWAY, 21ST FLOOR, SUITE 21V</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10018</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>false</aff10b5One>

    <nonDerivativeTable></nonDerivativeTable>

    <remarks>This &quot;Exit&quot; Form 4 is voluntarily filed to report that, in connection with the consummation of the initial business combination of Horizon Space Acquisition II Corp. (&quot;HSPT&quot;) on June 12, 2026 pursuant to the Business Combination Agreement dated May 9, 2025 by and among HSPT, SL Science Holding Limited, a Cayman Islands exempted company limited by shares, SL BIO Ltd., a Cayman Islands exempted company limited by shares, CW Mega Limited, a Cayman Islands exempted company limited by shares, and WW Century Limited, a Cayman Islands exempted company limited by shares, the Reporting Person no longer served as a director of HSPT or held any ordinary shares of HSPT after June 12, 2026, and therefore is no longer subject to Section 16 reporting.</remarks>

    <ownerSignature>
        <signatureName>/s/ Qian Xu</signatureName>
        <signatureDate>2026-06-16</signatureDate>
    </ownerSignature>
</ownershipDocument>
