Exhibit 16.1

Armanino ^LLP 15950 N. Dallas Parkway Suite 600 Dallas, TX 75248-6685 972 661 1843       main armanino.com

May 22, 2023

Securities and Exchange Commission

100 F Street, N.E.

Washington, DC 20549

Commissioners:

We have read the statements made by Iris Energy Limited of its Form 6-K dated May 22, 2023. We agree with the statements concerning our Firm contained therein.

Very truly yours,

Armanino^LLP