X0306 4 2022-12-29 0001878313 MAIA Biotechnology, Inc. MAIA 0001913199 Smith Stan 444 WEST LAKE STREET, CHICAGO IL 60606 1 Common Stock 2022-12-29 4 P 0 1471 3.49 A 512828 I See Footnote Common Stock 2022-12-30 4 P 0 500 3.50 A 513328 I See Footnote The purchases reported in this Form 4 were automatically effected pursuant to a previously executed purchasing plan of The Stan V. Smith Trust Dated 1993 that is intended to comply with Rule 10b5-1(c) promulgated under the Securities Exchange Act of 1934, as amended. These securities are beneficially owned by Mr. Smith through The Stan V. Smith Trust Dated 1993. The price reported is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $3.46 to $3.50, inclusive. The Reporting Person undertakes to provide to the staff of the Securities and Exchange Commission, to any security holder of the Issuer, or to the Issuer, upon request, full information regarding the number of shares purchased at each separate price within the range set forth above. /s/ Stan V. Smith 2023-01-03