X0306 4 2023-02-28 0 0001157601 MADRIGAL PHARMACEUTICALS, INC. MDGL 0001876996 Waltermire Robert E. C/O MADRIGAL PHARMACEUTICALS, INC. 200 BARR HARBOR DRIVE, SUITE 200 WEST CONSHOHOCKEN PA 19428 0 1 0 0 Senior VP, Chief Pharma Dev. Common Stock 2023-02-28 4 M 0 5000 87.92 A 10667 D Common Stock 2023-02-28 4 S 0 900 271.03 D 9767 D Common Stock 2023-02-28 4 S 0 4100 272.30 D 5667 D Common Stock 2023-03-01 4 M 0 5000 87.92 A 10667 D Common Stock 2023-03-01 4 S 0 1928 273.44 D 8739 D Common Stock 2023-03-01 4 S 0 1672 274.57 D 7067 D Common Stock 2023-03-01 4 S 0 1300 275.53 D 5767 D Common Stock 2023-03-01 4 S 0 100 276.19 D 5667 D Stock Option (Right to Buy) 87.92 2023-02-28 4 M 0 5000 0.00 D 2031-08-02 Common Stock 5000 30000 D Stock Option (Right to Buy) 87.92 2023-03-01 4 M 0 5000 0.00 D 2031-08-02 Common Stock 5000 25000 D All shares issued pursuant to the exercise of the options reported herein represent 10,000 shares underlying an overall option award of 35,000 shares. All exercised options had vested. As to the overall option for 35,000 shares, 25% of the shares underlying the option vested on August 2, 2022 and, thereafter, 6.25% of the shares vested, or will vest, on the last day of each successive three-month period, provided the Reporting Person continues in service with the Issuer on each such date. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $270.58 to $271.47, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and the footnotes below. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $271.82 to $272.77, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $273.00 to $274.00, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $274.06 to $274.99, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $275.18 to $276.18, inclusive. As attorney-in-fact for Reporting Person /s/ Brian J. Lynch 2023-03-02