X0306 4 2022-11-01 0 0001830214 Ginkgo Bioworks Holdings, Inc. DNA 0001873523 Shetty Reshma P. C/O GINKGO BIOWORKS HOLDINGS, INC. 27 DRYDOCK AVENUE BOSTON MA 02210 1 1 1 0 See remarks Class A Common Stock 2022-11-01 4 S 0 196307 2.768 D 22780078 D Class A Common Stock 2022-11-01 4 S 0 196308 2.768 D 22780078 I By Spouse Represents the number of shares sold by the Reporting Person or the Reporting Person's spouse to cover tax withholding obligations in connection with the vesting of RSUs. Sales to cover tax withholding obligations in connection with the vesting of such securities do not represent discretionary trades by the Reporting Person or the Reporting Person's spouse. The Issuer's equity incentive plans allow the Issuer to require that satisfaction of tax withholding obligations be funded by a "sell to cover" transaction. President, COO & Founder /s/ Karen Tepichin, Attorney-in-Fact 2022-11-03