X0306 4 2021-11-17 0 0001830214 Ginkgo Bioworks Holdings, Inc. DNA 0001873523 Shetty Reshma P. C/O GINKGO BIOWORKS HOLDINGS, INC. 27 DRYDOCK AVENUE BOSTON MA 02210 1 1 1 0 See Remarks Class A Common Stock 2022-09-30 4 M 0 773453 A 773453 D Class A Common Stock 2022-09-30 4 M 0 773453 A 773453 I By Spouse Class A Common Stock 2021-10-01 4 M 0 25782354 A 26555807 D Class A Common Stock 2021-10-01 4 M 0 25782354 A 26555807 I By Spouse Class A Common Stock 2022-10-03 4 S 0 343071 3.1216 D 26212736 D Class A Common Stock 2022-10-03 4 S 0 343072 3.1216 D 26212735 I By Spouse Class B Common Stock 2022-09-30 4 M 0 773453 D Class A Common Stock 2320344 D Class B Common Stock 2022-09-30 4 M 0 773453 D Class A Common Stock 2320344 I By Spouse Restricted Stock Units 2021-11-17 4 A 0 25782354 A Class A Common Stock 25782354 D Restricted Stock Units 2021-11-17 4 A 0 25782354 A Class A Common Stock 25782354 I By Spouse Restricted Stock Units 2022-10-01 4 M 0 25782354 D Class A Common Stock 0 D Restricted Stock Units 2022-10-01 4 M 0 25782354 D Class A Common Stock 0 I By Spouse Class B Common Stock Class A Common Stock 70389783 I By Reshma Padmini Shetty Living Trust Class B Common Stock Class A Common Stock 8245491 I By Reshma Padmini Shetty GRAT Class B Common Stock Class A Common Stock 70189783 I By Bartholomew Canton Living Trust Class B Common Stock Class A Common Stock 8245491 I By Bartholomew Canton GRAT Class B Common Stock Class A Common Stock 1291794 I By The Asha S. Canton Irrevocable Trust Class B Common Stock Class A Common Stock 1291794 I By The Adhira S. Canton Irrevocable Trust Represents the conversion of shares of Class B Common Stock to shares of Class A Common Stock. Shares of the Class B Common Stock may be converted into shares of Class A Common Stock, on a one-to-one basis, at the option of the holder at any time and have no expiration date. Represents restricted stock units (the "RSUs") granted prior to the business combination of Soaring Eagle Acquisition Corp. and Ginkgo Bioworks, Inc. in September 2021 (the "Merger"), which became contingent rights to acquire equity securities of the Issuer upon consummation of the Merger. At the time of grant, the RSUs were subject to both a service-based vesting condition and a performance-based vesting condition. On November 17, 2021, the board of directors of the Issuer modified the vesting terms of RSUs, such that the Merger was deemed to have satisfied the performance condition for vesting effective as of March 15, 2022. The service-based vesting condition was satisfied on October 1, 2022, and the Issuer elected to deliver one share of Class A Common Stock for each RSU. Such shares of Class A Common Stock may be exchanged for shares of Class B Common Stock. Represents the number of shares sold by the Reporting Person or the Reporting Person's spouse to cover tax withholding obligations in connection with the vesting of RSUs. Sales to cover tax withholding obligations in connection with the vesting of such securities do not represent discretionary trades by the Reporting Person or the Reporting Person's spouse. The Issuer's equity incentive plans allow the Issuer to require that satisfaction of tax withholding obligation to be funded by a "sell to cover" transaction. Includes shares of Class B Common Stock that are subject to vesting conditions. President, COO & Founder /s/ Karen Tepichin, Attorney-in-Fact 2022-10-04