<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001871703</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001492691</issuerCik>
      <issuerName>Knight-Swift Transportation Holdings Inc.</issuerName>
      <secFileNumber>001-35007</secFileNumber>
      <issuerAddress>
        <com:street1>2200 SOUTH 75TH AVENUE</com:street1>
        <com:city>PHOENIX</com:city>
        <com:stateOrCountry>AZ</com:stateOrCountry>
        <com:zipCode>85043</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>602-269-9700</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Dove Reid</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Stephens Inc.</name>
        <address>
          <com:street1>111 Center St</com:street1>
          <com:city>Little Rock</com:city>
          <com:stateOrCountry>AR</com:stateOrCountry>
          <com:zipCode>72201</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>50000</noOfUnitsSold>
      <aggregateMarketValue>3512290.00</aggregateMarketValue>
      <noOfUnitsOutstanding>162756000</noOfUnitsOutstanding>
      <approxSaleDate>07/31/2026</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>07/05/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Partial consideration received in sale of AAA Cooper Transportation to Knight-Swift Transportation Holdings, Inc.</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>219154</amountOfSecuritiesAcquired>
      <paymentDate>07/05/2021</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>The shares covered by the filing will be sold by Dove Family Foundation, Reid Dove as Vice President.</remarks>
    <noticeSignature>
      <noticeDate>07/31/2026</noticeDate>
      <signature>Reid Dove</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
