<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2022-02-10</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001870833</issuerCik>
        <issuerName>RiverNorth Managed Duration Municipal Income Fund II, Inc.</issuerName>
        <issuerTradingSymbol>RMMZ</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001864804</rptOwnerCik>
            <rptOwnerName>Denlinger Michael</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O MACKAY SHIELDS LLC</rptOwnerStreet1>
            <rptOwnerStreet2>1345 AVENUE OF THE AMERICAS, 42ND FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10105</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOther>true</isOther>
            <otherText>Portfolio Manager</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Shares of Common Stock</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">The Reporting Person does not own any of the Issuer's equity securities and is filing this report solely in his capacity as a Portfolio Manager.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Michael Denlinger by his attorney-in-fact Chris Fitzgerald, Managing Director, CCO</signatureName>
        <signatureDate>2022-02-08</signatureDate>
    </ownerSignature>
</ownershipDocument>
