X0508 4 2025-02-24 0 0001870404 CERO THERAPEUTICS HOLDINGS, INC. CERO 0001378251 Patel Shami CERO THERAPEUTICS HOLDINGS, INC. 201 HASKINS WAY, SUITE 230 SOUTH SAN FRANCISCO CA 94080 1 0 0 0 0 Stock Option (Right to Buy) 0.0951 2025-02-24 4 A 0 127500 0.00 A 2034-10-10 Common Stock 127500 255000 D On October 11, 2024, the Reporting Person was granted an option to purchase 255,000 shares of Common Stock, which vest in two equal installments subject to the satisfaction of certain performance criteria. On February 24, 2025, the Issuer's Board of Directors confirmed that the performance criteria had been met with regards to the second installment, resulting in the vesting of 127,500 shares. /s/ Christopher B. Ehrlich, Attorney-in-Fact 2025-02-26