144 0001870278 XXXXXXXX LIVE 0001104506 INSMED INC 000-30739 700 US Highway 202/206 Bridgewater NJ 08807 9089779900 Michael Smith Officer Common Merrill Lynch

1800 K ST NW Suite 800 Washington DC 20006

19638 2964929 215551896 03/30/2026 NASDAQ Common 03/30/2026 Stock Plan Activity Issuer N 19638 03/30/2026 n/a N Michael Smith

700 US Highway 202/206 Bridgewater NJ 08807

Common 02/24/2026 24774 3859153 Michael Smith

700 US Highway 202/206 Bridgewater NJ 08807

Common 02/03/2026 640 100012 Michael Smith

700 US Highway 202/206 Bridgewater NJ 08807

Common 01/08/2026 1053 183401 Michael Smith

700 US Highway 202/206 Bridgewater NJ 08807

Common 01/07/2026 709 124124 Michael Smith

700 US Highway 202/206 Bridgewater NJ 08807

Common 01/06/2026 1396 241968 03/30/2026 11/07/2025 Michael Smith