<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2021-09-30</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001868726</issuerCik>
        <issuerName>OLAPLEX HOLDINGS, INC.</issuerName>
        <issuerTradingSymbol>OLPX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001534778</rptOwnerCik>
            <rptOwnerName>White Emily</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O OLAPLEX HOLDINGS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>1178 COAST VILLAGE RD, SUITE 1-520</rptOwnerStreet2>
            <rptOwnerCity>SANTA BARBARA</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>93108</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>23476117</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By: Anthos Capital IV, L.P.</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>148064</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By: Anthos Tribe, L.P.</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Shares are held by Anthos Capital IV, L.P. (&quot;Anthos Capital IV&quot;). Anthos Associates IV, L.P. (&quot;Anthos Associates IV&quot;) is the general partner of Anthos Capital IV and Anthos Associates GP IV, LLC (&quot;Anthos Associates GP IV&quot;) is the general partner of Anthos Associates IV. Paul Farr and Bryan Kelly are the sole managers of Anthos Associates GP IV. Ms. White is the spouse of Mr. Kelly and as a result also may be deemed to have beneficial ownership of the shares held directly by Anthos Capital IV. Ms. White disclaims beneficial ownership of the shares held by Anthos Capital IV, except to the extent of her pecuniary interest therein.</footnote>
        <footnote id="F2">Shares are held by Anthos Tribe, L.P. (&quot;Anthos Tribe&quot;). Anthos Tribe GP, LLC (&quot;Anthos Tribe GP&quot;) is the general partner of Anthos Tribe. Paul Farr and Bryan Kelly are the sole managers of Anthos Tribe GP. White is the spouse of Mr. Kelly and as a result also may be deemed to have beneficial ownership of the shares held directly by Anthos Tribe. Ms. White disclaims beneficial ownership of the shares held by Anthos Tribe, except to the extent of her pecuniary interest therein.</footnote>
    </footnotes>

    <remarks>Exhibits 24.1 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Eric Tiziani, attorney-in-fact</signatureName>
        <signatureDate>2021-09-30</signatureDate>
    </ownerSignature>
</ownershipDocument>
