144 0001652410 XXXXXXXX LIVE 0001867096 XERIS BIOPHARMA HOLDINGS, INC. 001-40880 1375 West Fulton Street, Suite 1300 Chicago IL 60607 8444455704 BETH HECHT Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

49998 395984.16 172642055 07/01/2026 NASDAQ Common 01/31/2023 Restricted Stock Units Issuer N 37409 01/31/2023 N/A Common 06/30/2020 Employee Stock Purchase Plan Issuer N 10026 06/30/2020 Cash Common 03/13/2020 Open Market Purchase Issuer N 2563 03/13/2020 Cash N 10b5-1 Sales for BETH HECHT

1375 West Fulton Street, Suite 1300 Chicago IL 60607

Common 06/01/2026 16667 100982.35 10b5-1 Sales for BETH HECHT

1375 West Fulton Street, Suite 1300 Chicago IL 60607

Common 05/01/2026 16667 103805.37 The 10,026 securities to be sold were acquired upon the acquisition of employee stock purchase plan shares during the period of 06/30/2020 through 06/30/2024. 07/01/2026 08/08/2025 /s/ Beth Hecht