144 0001652410 XXXXXXXX LIVE 0001867096 XERIS BIOPHARMA HOLDINGS, INC. 001-40880 1375 West Fulton Street, Suite 1300 Chicago IL 60607 8444455704 BETH HECHT Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

66668 408008.16 165924289 03/02/2026 NASDAQ Common 01/03/2024 Restricted Stock Units Issuer N 66668 01/03/2024 N/A N 10b5-1 Sales for BETH P HECHT

1375 West Fulton Street, Suite 1300 Chicago IL 60607

Common 02/02/2026 16667 124147.15 10b5-1 Sales for BETH P HECHT

1375 West Fulton Street, Suite 1300 Chicago IL 60607

Common 01/02/2026 16667 123775.48 The securities to be sold were acquired upon the vesting of restricted stock units on 01/03/2024 and 01/31/2024. 03/02/2026 08/08/2025 /s/ Beth P. Hecht