X0306 4 2022-04-08 0001228627 Ocuphire Pharma, Inc. OCUP 0001866191 Pepose Jay C/O OCUPHIRE PHARMA, INC. 37000 GRAND RIVER AVE, SUITE 120 FARMINGTON HILLS MI 48335 true Stock Option (right to buy) 2.9 2022-04-08 4 A 0 50000 0 A 2032-04-07 Common Stock 50000 50000 D The option will vest with respect to 12,500 shares on March 31, 2023, and then with respect to 1,041 shares on the last day of each month from April 2023 through February 2026 and with respect to 1,065 shares at the end of March 2026, subject to the Reporting Person's continuing service through each applicable vesting date. /s/ Emily J. Johns, by Power of Attorney 2022-04-13