X0508 4 2024-01-24 0001503802 Karyopharm Therapeutics Inc. KPTI 0001865796 Cheng Sohanya Roshan C/O KARYOPHARM THERAPEUTICS INC. 85 WELLS AVENUE NEWTON MA 02459 false true false false EVP & Chief Commercial Officer false Common Stock 2024-01-24 4 A false 14167 0.0 A 221499 D Represents the number of shares of the issuer's common stock underlying performance-based restricted stock units ("PSUs") granted in February 2023 that have been earned based on the level of achievement of a certain clinical milestone, as certified by the issuer's compensation committee on January 24, 2024. Each earned PSU represents the contingent right to receive one share of the issuer's common stock upon vesting. The earned PSUs will vest on February 28, 2024, the first anniversary of the grant date, subject to continued employment through such vesting date. Includes 3,246 shares acquired by the reporting person under the Karyopharm Therapeutics Inc. Amended and Restated 2013 Employee Stock Purchase Plan. /s/Nancy Smith as Attorney-in-Fact for Sohanya Cheng 2024-01-25