Exscientia plc

The Schrödinger Building

Oxford Science Park

Oxford OX4 4GE

United Kingdom

April 2, 2024

Via EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attn:	Jimmy McNamara
Re:	Exscientia plc
	Registration Statement on Form F-3 (File No. 333-278132)
	Request for Acceleration of Effective Date  Acceleration Request             Requested Date:         April 4, 2024             Requested Time:        4:00 p.m. Eastern Time

Mr. McNamara:

In accordance with Rule 461 under the Securities Act of 1933, as amended, the undersigned registrant (the “Registrant”) hereby requests that the Securities and Exchange Commission take appropriate action to cause the above-referenced Registration Statement on Form F-3 (File No. 333-278132) (the “Registration Statement”) to become effective on April 4, 2024, at 4:00 p.m. Eastern Time, or as soon thereafter as is practicable.

Once the Registration Statement has been declared effective, please orally confirm that event with Dayne Brown of Cooley LLP, counsel to the Registrant, at (212) 479 6712.

[Signature page follows]

Very truly yours,
Exscientia plc
By:	/s/ David Hallett
	David Hallett, Ph.D.
	Interim Chief Executive Officer and Director

cc: Daniel Ireland, Exscientia plc    

      David Boles, Cooley (UK) LLP

Signature Page to Company Acceleration Request – F-3