Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in the Registration Statements on Form S-3 (No. 333-249475 and 333-238568) and Form S-8 (Nos. 333-191786, 333-196515, 333-228019, and 333-264876) of Ameren Corporation of our report dated February 21, 2023, relating to the financial statements, financial statement schedules and the effectiveness of internal control over financial reporting, which appears in this Form 10-K.

/s/ PricewaterhouseCoopers LLP

St. Louis, Missouri

February 21, 2023