X0306 4 2022-07-05 0 0001403752 Zymeworks Inc. ZYME 0001864141 Josephson Neil C/O ZYMEWORKS INC. 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER A1 V5T 1G4 BRITISH COLUMBIA, CANADA 0 1 0 0 Chief Medical Officer Common Shares 2022-07-05 4 A 0 1525 4.51 A 11039 D Shares purchased pursuant to the Issuer's Amended and Restated Employee Stock Purchase Plan (ESPP) for the ESPP purchase period January 1, 2022 through June 30, 2022. In accordance with the ESPP, these shares were purchased at a price equal to 85% the closing price of the Issuer's common shares on June 30, 2022. /s/ Daniel Dex, Attorney-in-Fact 2022-07-05