SCHEDULE 13G/A 0001193125-24-131732 0001863769 XXXXXXXX LIVE 2 Common Stock 01/31/2025 0001370053 AnaptysBio, Inc. 032724106 10770 Wateridge Circle, Suite 210 San Diego CA 92121 Rule 13d-1(c) Frazier Life Sciences Public Fund, L.P. DE 0.00 148844.00 0.00 148844.00 0.5 PN The shares listed in rows 6, 8 and 9 consist of 148,844 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. FHMLSP, L.P. DE 0.00 148844.00 0.00 148844.00 148844.00 0.5 PN The shares listed in rows 6, 8 and 9 consist of 148,844 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. FHMLSP, L.L.C. DE 0.00 148844.00 0.00 148844.00 148844.00 0.5 OO The shares listed in rows 6, 8 and 9 consist of 148,844 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. Frazier Life Sciences Public Overage Fund, L.P. DE 0.00 18902.00 0.00 18902.00 18902.00 0.1 PN The shares listed in rows 6, 8 and 9 consist of 18,902 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Overage Fund, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. FHMLSP Overage, L.P. DE 0.00 18902.00 0.00 18902.00 18902.00 0.1 PN The shares listed in rows 6, 8 and 9 consist of 18,902 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Overage Fund, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. FHMLSP Overage, L.L.C. DE 0.00 18902.00 0.00 18902.00 18902.00 0.1 OO The shares listed in rows 6, 8 and 9 consist of 18,902 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Overage Fund, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. Frazier Life Sciences X, L.P. DE 0.00 18715.00 0.00 18715.00 18715.00 0.1 PN The shares listed in rows 6, 8 and 9 consist of 18,715 shares of Common Stock held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.P. is the general partner of FHMLS X, L.P. Patrick J. Heron and James N. Topper are the members of FHMLS X, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences X, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. FHMLS X, L.P. DE 0.00 18715.00 0.00 18715.00 18715.00 0.1 PN The shares listed in rows 6, 8 and 9 consist of 18,715 shares of Common Stock held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.P. is the general partner of FHMLS X, L.P. Patrick J. Heron and James N. Topper are the members of FHMLS X, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences X, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. FHMLS X, L.L.C. DE 0.00 18715.00 0.00 18715.00 18715.00 0.1 OO The shares listed in rows 6, 8 and 9 consist of 18,715 shares of Common Stock held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLS X, L.P. Patrick J. Heron and James N. Topper are the members of FHMLS X, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences X, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. Frazier Life Sciences XI, L.P. DE 0.00 40222.00 0.00 40222.00 40222.00 0.1 PN The shares listed in rows 6, 8 and 9 consist of 40,222 shares of Common Stock held directly by Frazier Life Sciences XI, L.P. FHMLS XI, L.P. is the general partner of Frazier Life Sciences XI, L.P. and FHMLS XI, L.L.C. is the general partner of FHMLS XI, L.P. Patrick J. Heron, James N. Topper and Daniel Estes are the members of FHMLS XI, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences XI, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. FHMLS XI, L.P. DE 0.00 40222.00 0.00 40222.00 40222.00 0.1 PN The shares listed in rows 6, 8 and 9 consist of 40,222 shares of Common Stock held directly by Frazier Life Sciences XI, L.P. FHMLS XI, L.P. is the general partner of Frazier Life Sciences XI, L.P. and FHMLS XI, L.L.C. is the general partner of FHMLS XI, L.P. Patrick J. Heron, James N. Topper and Daniel Estes are the members of FHMLS XI, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences XI, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. FHMLS XI, L.L.C. DE 0.00 40222.00 0.00 40222.00 40222.00 0.1 OO The shares listed in rows 6, 8 and 9 consist of 40,222 shares of Common Stock held directly by Frazier Life Sciences XI, L.P. FHMLS XI, L.P. is the general partner of Frazier Life Sciences XI, L.P. and FHMLS XI, L.L.C. is the general partner of FHMLS XI, L.P. Patrick J. Heron, James N. Topper and Daniel Estes are the members of FHMLS XI, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences XI, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. Frazier Healthcare VII, L.P. DE 0.00 121206.00 0.00 121206.00 121206.00 0.4 PN The shares listed in rows 6, 8 and 9 consist of 121,206 shares of Common Stock held directly by Frazier Healthcare VII, L.P. FHM VII, L.P. is the general partner of Frazier Healthcare VII, L.P. and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Patrick J. Heron, James N. Topper, Alan Frazier, Nader Naini, Nathan Every and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. Frazier Healthcare VII-A, L.P. DE 0.00 34540.00 0.00 34540.00 34540.00 0.1 PN The shares listed in rows 6, 8 and 9 consist of 34,540 shares of Common Stock held directly by Frazier Healthcare VII-A, L.P. FHM VII, L.P. is the general partner of Frazier Healthcare VII-A, L.P. and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Patrick J. Heron, James N. Topper, Alan Frazier, Nader Naini, Nathan Every and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII-A, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. FHM VII, L.P. DE 0.00 155746.00 0.00 155746.00 155746.00 0.5 PN The shares listed in rows 6, 8 and 9 consist of (i) 121,206 shares of Common Stock held directly by Frazier Healthcare VII, L.P. and (ii) 34,540 shares of Common Stock held directly by Frazier Healthcare VII-A, L.P. FHM VII, L.P. is the general partner of both Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Patrick J. Heron, James N. Topper, Alan Frazier, Nader Naini, Nathan Every and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. FHM VII, L.L.C. DE 0.00 155746.00 0.00 155746.00 155746.00 0.5 OO The shares listed in rows 6, 8 and 9 consist of (i) 121,206 shares of Common Stock held directly by Frazier Healthcare VII, L.P. and (ii) 34,540 shares of Common Stock held directly by Frazier Healthcare VII-A, L.P. FHM VII, L.P. is the general partner of both Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Patrick J. Heron, James N. Topper, Alan Frazier, Nader Naini, Nathan Every and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. James N. Topper X1 80812.00 382429.00 80812.00 382429.00 463241.00 1.5 IN The 80,812 shares listed in rows 5 and 7 are held directly by James N. Topper. The 382,429 shares listed in rows 6 and 8 consist of (i) 148,844 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P., (ii) 18,902 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P., (iii) 18,715 shares of Common Stock held directly by Frazier Life Sciences X, L.P., (iv) 40,222 shares of Common Stock held directly by Frazier Life Sciences XI, L.P. (v) 121,206 shares of Common Stock held directly by Frazier Healthcare VII, L.P. and (vi) 34,540 shares of Common Stock held directly by Frazier Healthcare VII-A, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Overage Fund, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. Patrick J. Heron and James N. Topper are the members of FHMLS X, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences X, L.P. FHMLS XI, L.P. is the general partner of Frazier Life Sciences XI, L.P. and FHMLS XI, L.L.C. is the general partner of FHMLS XI, L.P. Patrick J. Heron, James N. Topper and Daniel Estes are the members of FHMLS XI, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences XI, L.P. FHM VII, L.P. is the general partner of both Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Patrick J. Heron, James N. Topper, Alan Frazier, Nader Naini, Nathan Every and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. Patrick J. Heron X1 9110.00 382429.00 9110.00 382429.00 391539.00 1.3 IN The 9,110 shares listed in rows 5 and 7 are held directly by The Heron Living Trust 11/30/2004. Patrick J. Heron is the co-trustee of The Heron Living Trust 11/30/2004 and has voting and investment power over the shares held by The Heron Living Trust 11/30/2004. The 382,429 shares listed in rows 6 and 8 consist of (i) 148,844 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P., (ii) 18,902 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P., (iii) 18,715 shares of Common Stock held directly by Frazier Life Sciences X, L.P., (iv) 40,222 shares of Common Stock held directly by Frazier Life Sciences XI, L.P. (v) 121,206 shares of Common Stock held directly by Frazier Healthcare VII, L.P. and (vi) 34,540 shares of Common Stock held directly by Frazier Healthcare VII-A, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Overage Fund, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. Patrick J. Heron and James N. Topper are the members of FHMLS X, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences X, L.P. FHMLS XI, L.P. is the general partner of Frazier Life Sciences XI, L.P. and FHMLS XI, L.L.C. is the general partner of FHMLS XI, L.P. Patrick J. Heron, James N. Topper and Daniel Estes are the members of FHMLS XI, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences XI, L.P. FHM VII, L.P. is the general partner of both Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Patrick J. Heron, James N. Topper, Alan Frazier, Nader Naini, Nathan Every and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. Albert Cha DE 0.00 167746.00 0.00 167746.00 167746.00 0.6 IN The shares listed in rows 6, 8 and 9 consist of (i) 148,844 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P., and (ii) 18,902 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Overage Fund, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. James Brush X1 0.00 167746.00 0.00 167746.00 167746.00 0.6 IN The shares listed in rows 6, 8 and 9 consist of (i) 148,844 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P., and (ii) 18,902 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Overage Fund, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. Daniel Estes X1 0.00 40222.00 0.00 40222.00 40222.00 0.1 IN The shares listed in rows 6, 8 and 9 consist of 40,222 shares of Common Stock held directly by Frazier Life Sciences XI, L.P. FHMLS XI, L.P. is the general partner of Frazier Life Sciences XI, L.P. and FHMLS XI, L.L.C. is the general partner of FHMLS XI, L.P. Patrick J. Heron, James N. Topper and Daniel Estes are the members of FHMLS XI, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences XI, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. Alan Frazier X1 0.00 155746.00 0.00 155746.00 155746.00 0.5 IN The shares listed in rows 6, 8 and 9 consist of (i) 121,206 shares of Common Stock held directly by Frazier Healthcare VII, L.P. and (ii) 34,540 shares of Common Stock held directly by Frazier Healthcare VII-A, L.P. FHM VII, L.P. is the general partner of both Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Patrick J. Heron, James N. Topper, Alan Frazier, Nader Naini, Nathan Every and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. Nader Naini X1 0.00 155746.00 0.00 155746.00 155746.00 0.5 IN The shares listed in rows 6, 8 and 9 consist of (i) 121,206 shares of Common Stock held directly by Frazier Healthcare VII, L.P. and (ii) 34,540 shares of Common Stock held directly by Frazier Healthcare VII-A, L.P. FHM VII, L.P. is the general partner of both Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Patrick J. Heron, James N. Topper, Alan Frazier, Nader Naini, Nathan Every and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. Nathan Every X1 4623.00 155746.00 4623.00 155746.00 160369.00 0.5 IN The 4,623 shares listed in rows 5 and 7 are held directly by Nathan Every. The 155,746 shares listed in rows 6 and 8 consist of (i) 121,206 shares of Common Stock held directly by Frazier Healthcare VII, L.P. and (ii) 34,540 shares of Common Stock held directly by Frazier Healthcare VII-A, L.P. FHM VII, L.P. is the general partner of both Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Patrick J. Heron, James N. Topper, Alan Frazier, Nader Naini, Nathan Every and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. Brian Morfitt X1 5369.00 155746.00 5369.00 155746.00 161115.00 0.5 IN The 5,369 shares listed in rows 5 and 7 are held directly by Brian Morfitt. The 155,746 shares listed in rows 6 and 8 consist of (i) 121,206 shares of Common Stock held directly by Frazier Healthcare VII, L.P. and (ii) 34,540 shares of Common Stock held directly by Frazier Healthcare VII-A, L.P. FHM VII, L.P. is the general partner of both Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. and FHM VII, L.L.C. is the general partner of FHM VII, L.P. Patrick J. Heron, James N. Topper, Alan Frazier, Nader Naini, Nathan Every and Brian Morfitt are the members of FHM VII, L.L.C. and therefore share voting and investment power over the shares held by Frazier Healthcare VII, L.P. and Frazier Healthcare VII-A, L.P. The percentage listed in row 11 is calculated based on 30,428,682 shares of Common Stock outstanding on October 31, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 5, 2024. AnaptysBio, Inc. 10770 Wateridge Circle, Suite 210, San Diego, CA, 92121. Name of Person Filing: The entities and persons filing this statement (collectively, the "Reporting Persons") are: Frazier Life Sciences Public Fund, L.P. ("FLSPF") FHMLSP, L.P. FHMLSP, L.L.C. Frazier Life Sciences Public Overage Fund, L.P. ("FLSPOF") FHMLSP Overage, L.P. FHMLSP Overage, L.L.C. Frazier Healthcare VII, L.P. ("FH VII") Frazier Healthcare VII-A, L.P. ("FH VII-A") FHM VII, L.P. FHM VII, L.L.C. Frazier Life Sciences X, L.P. ("FLS X") FHMLS X, L.P. FHMLS X, L.L.C. Frazier Life Sciences XI, L.P. ("FLS XI") FHMLS XI, L.P. FHMLS XI, L.L.C. James N. Topper ("Topper") Patrick J. Heron ("Heron") Albert Cha ("Cha") James Brush ("Brush") Daniel Estes ("Estes") Alan Frazier ("Frazier") Nader Naini ("Naini") Nathan Every ("Every") Brian Morfitt ("Morfitt" and together with Topper, Heron, Cha, Brush, Estes, Frazier, Naini and Every, the "Members") The address and principal business office of the Reporting Persons is: c/o Frazier Life Sciences Management, L.P. 1001 Page Mill Rd, Building 4, Suite B Palo Alto, CA 94304 Entities: FLSPF - Delaware, U.S.A. FHMLSP, L.P. - Delaware, U.S.A. FHMLSP, L.L.C. - Delaware, U.S.A. FLSPOF - Delaware, U.S.A. FHMLSP Overage, L.P. - Delaware, U.S.A. FHMLSP Overage, L.L.C. - Delaware, U.S.A. FH VII - Delaware, U.S.A. FH VII-A - Delaware, U.S.A. FHM VII, L.P. - Delaware, U.S.A. FHM VII, L.L.C. - Delaware, U.S.A. FLS X - Delaware, U.S.A. FHMLS X, L.P. - Delaware, U.S.A. FHMLS X, L.L.C. - Delaware, U.S.A. FLS XI - Delaware, U.S.A. FHMLS XI, L.P. - Delaware, U.S.A. FHMLS XI, L.L.C. - Delaware, U.S.A. Individuals: Topper - United States Citizen Heron - United States Citizen Cha - United States Citizen Brush - United States Citizen Estes - United States Citizen Frazier - United States Citizen Naini - United States Citizen Every - United States Citizen Morfitt - United States Citizen Y The information contained in row 9 of each Reporting Person's cover page to this Schedule 13G (including the footnotes thereto) is incorporated by reference. The information contained in row 11 of each Reporting Person's cover page to this Schedule 13G (including the footnotes thereto) is incorporated by reference. The information contained in row 5 of each Reporting Person's cover page to this Schedule 13G (including the footnotes thereto) is incorporated by reference. The information contained in row 6 of each Reporting Person's cover page to this Schedule 13G (including the footnotes thereto) is incorporated by reference. The information contained in row 7 of each Reporting Person's cover page to this Schedule 13G (including the footnotes thereto) is incorporated by reference. The information contained in row 8 of each Reporting Person's cover page to this Schedule 13G (including the footnotes thereto) is incorporated by reference. N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 99.1 Joint Filing Agreement Frazier Life Sciences Public Fund, L.P. /s/ Steve R. Bailey 02/14/2025 FHMLSP, L.P. /s/ Steve R. Bailey 02/14/2025 FHMLSP, L.L.C. /s/ Steve R. Bailey 02/14/2025 Frazier Life Sciences Public Overage Fund, L.P. /s/ Steve R. Bailey 02/14/2025 FHMLSP Overage, L.P. /s/ Steve R. Bailey 02/14/2025 FHMLSP Overage, L.L.C. /s/ Steve R. Bailey 02/14/2025 Frazier Life Sciences X, L.P. /s/ Steve R. Bailey 02/14/2025 FHMLS X, L.P. /s/ Steve R. Bailey 02/14/2025 FHMLS X, L.L.C. /s/ Steve R. Bailey 02/14/2025 Frazier Life Sciences XI, L.P. /s/ Steve R. Bailey 02/14/2025 FHMLS XI, L.P. /s/ Steve R. Bailey 02/14/2025 FHMLS XI, L.L.C. /s/ Steve R. Bailey 02/14/2025 Frazier Healthcare VII, L.P. /s/ Steve R. Bailey 02/14/2025 Frazier Healthcare VII-A, L.P. /s/ Steve R. Bailey 02/14/2025 FHM VII, L.P. /s/ Steve R. Bailey 02/14/2025 FHM VII, L.L.C. /s/ Steve R. Bailey 02/14/2025 James N. Topper /s/ Steve R. Bailey 02/14/2025 Patrick J. Heron /s/ Steve R. Bailey 02/14/2025 Albert Cha /s/ Steve R. Bailey 02/14/2025 James Brush /s/ Steve R. Bailey 02/14/2025 Daniel Estes /s/ Steve R. Bailey 02/14/2025 Alan Frazier /s/ Steve R. Bailey 02/14/2025 Nader Naini /s/ Steve R. Bailey 02/14/2025 Nathan Every /s/ Steve R. Bailey 02/14/2025 Brian Morfitt /s/ Steve R. Bailey 02/14/2025