X0202 SCHEDULE 13G/A 0001104659-21-119801 0001804218 XXXXXXXX LIVE 2 Common Stock, $0.0001 par value 06/30/2026 0001863127 TYRA BIOSCIENCES, INC. 90240B106 2656 State Street Carlsbad CA 92008 Rule 13d-1(c) Nextech VI Oncology SCSp b N4 3553585.00 0.00 3553585.00 0.00 3553585.00 6.0 PN Nextech VI GP S.a. r.l. b N4 3553585.00 0.00 3553585.00 0.00 3553585.00 6.0 OO Ian Charoub b V7 0.00 3553585.00 0.00 3553585.00 3553585.00 6.0 IN Costas Constantinides b G4 0.00 3553585.00 0.00 3553585.00 3553585.00 6.0 IN Rocco Sgobbo b V8 0.00 3553585.00 0.00 3553585.00 3553585.00 6.0 IN TYRA BIOSCIENCES, INC. 2656 State Street, Carlsbad, CA, 92008. The names of the persons filing this report (collectively, the "Reporting Persons") are: Nextech VI Oncology SCSp ("Nextech VI LP") Nextech VI GP S.a. r.l. ("Nextech VI GP") Ian Charoub ("Charoub") Costas Constantinides ("Constantinides") Rocco Sgobbo ("Sgobbo") The Reporting Persons expressly disclaim status as a "group" for purposes of this Schedule 13G. Bahnhofstrasse 18 Zurich, Switzerland 8001 Nextech VI LP Luxembourg Nextech VI GP Luxembourg Charoub Sweden Constantinides Cyprus Sgobbo Switzerland Y Row 9 of each Reporting Person's cover page to this Schedule 13G sets forth the aggregate number of shares of common stock of the Issuer beneficially owned by such Reporting Person as of June 30, 2026 and is incorporated by reference. Nextech VI LP holds 3,553,585 shares of common stock of the Issuer. Nextech VI GP serves as the sole general partner of Nextech VI LP and Charoub, Constantinides and Sgobbo are members of the board of managers of Nextech VI GP. Each of Nextech VI GP, Charoub, Constantinides and Sgobbo possesses power to direct the voting and disposition of the securities held by Nextech VI LP. Row 11 of each Reporting Person's cover page to this Schedule 13G sets forth the percentages of the shares of common stock of the Issuer beneficially owned by such Reporting Person as of June 30, 2026 and is incorporated by reference. The percentage set forth in each row 11 is based upon 59,470,381 shares of common stock outstanding as of May 8, 2026, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (the "SEC") on May 13, 2026. Row 5 of each Reporting Person's cover page to this Schedule 13G sets forth the sole power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person as of June 30, 2026 and is incorporated by reference. Row 6 of each Reporting Person's cover page to this Schedule 13G sets forth the shared power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person as of June 30, 2026 and is incorporated by reference. Row 7 of each Reporting Person's cover page to this Schedule 13G sets forth the sole power to dispose or to direct the disposition of securities of the Issuer beneficially owned by such Reporting Person as of June 30, 2026 and is incorporated by reference. Row 8 of each Reporting Person's cover page to this Schedule 13G sets forth the shared power to dispose or to direct the disposition of securities of the Issuer beneficially owned by such Reporting Person as of June 30, 2026 and is incorporated by reference. Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. Exhibit 99.1 Joint Filing Agreement (incorporated by reference to Exhibit A to the Schedule 13G filed by the Reporting Persons with the SEC on November 14, 2024). Nextech VI Oncology SCSp /s/ Ian Charoub 08/14/2026 /s/ Costas Constantinides 08/14/2026 Nextech VI GP S.a. r.l. /s/ Ian Charoub 08/14/2026 /s/ Costas Constantinides 08/14/2026 Ian Charoub /s/ Ian Charoub 08/14/2026 Costas Constantinides /s/ Costas Constantinides 08/14/2026 Rocco Sgobbo /s/ Rocco Sgobbo 08/14/2026